环状蛋白质结构域的化学合成：折叠辅助环化的证据。
Chemical Synthesis of a Circular Protein Domain: Evidence for Folding-Assisted Cyclization.
作者信息
Camarero Julio A, Pavel Joanna, Muir Tom W
机构信息
The Laboratory of Synthetic Protein Chemistry, The Rockefeller University, Box 223, 1230 York Avenue, New York, NY 10021 (USA), Fax: Int. code+(1) 212 327-7358.
出版信息
Angew Chem Int Ed Engl. 1998 Feb 16;37(3):347-349. doi: 10.1002/(SICI)1521-3773(19980216)37:3<347::AID-ANIE347>3.0.CO;2-5.
Abstract
Extremely fast cyclization of the linear polypeptide precursor 1 takes place to form 2. The reaction appears to be assisted by the native fold of 1, which positions the reactive ends in close proximity. The circular topology has no influence on the folding or function of 2.
摘要
线性多肽前体1发生极快速的环化反应形成2。该反应似乎受到1的天然折叠的辅助，天然折叠将反应性末端定位在紧密相邻的位置。环状拓扑结构对2的折叠或功能没有影响。
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