一种含葡萄糖的醚脂（Glc-PAF）作为血小板活化因子的抗增殖类似物。
A Glucose-Containing Ether Lipid (Glc-PAF) as an Antiproliferative Analogue of the Platelet-Activating Factor.
作者信息
Mickeleit Michael, Wieder Thomas, Arnold Michael, Geilen Christoph C, Mulzer Johann, Reutter Werner
机构信息
Institut für Organische Chemie der Freien Universität Berlin.
Institut für Molekularbiologie und Biochemie der Freien Universität, Arnimallee 22, D-14195 Berlin (Germany), Fax: Int. code + (49) 30 838-2141.
出版信息
Angew Chem Int Ed Engl. 1998 Feb 16;37(3):351-353. doi: 10.1002/(SICI)1521-3773(19980216)37:3<351::AID-ANIE351>3.0.CO;2-P.
A new group of active substances, to which 1 belongs, inhibit cell proliferation and initiate programmed cell death (apoptosis) in keratinocytes. The glucosylated phospholipid 1 was synthesized from (S)-isopropylideneglycerol in nine steps with an overall yield of 25 %.
属于该类的一组新的活性物质可抑制角质形成细胞的增殖并引发程序性细胞死亡（凋亡）。糖基化磷脂1由（S）-异亚丙基甘油经九步合成，总产率为25%。
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