[Induction of hepatic tyrosine transaminase in rats by phenothiazine derivatives and analogs].
作者信息
Amory C, Mainard F, Bousquet B
出版信息
C R Acad Hebd Seances Acad Sci D. 1978 Jul 10;287(2):97-100.
PMID:29715
Abstract
We have showed induction of tyrosine-alpha-ketoglutarate transaminase in hepatic cytosol of Rats (Wistar strain) five hours after intraperitoneal administration of tricyclic compounds (phenothiazine, iminodibenzyl, thioxanthene, thiophenylpyridylamin, dibenzocycloheptadiene, dibenzoxepin derivatives). Chemical structure of these molecules is very important: sulfur atom (phenothiazine, thioxanthene), some substituants like chlorine (chlorpromazine, chlorprothixene) and 2'-dimethylaminopropyl chain (promethazine) increase this inductive effect.
摘要
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