Podoplanin表达作为胃癌的一个预后因素

Podoplanin Expression as a Prognostic Factor in Gastric Cancer.

作者信息

Maruyama Suguru, Furuya Shinji, Shiraishi Kensuke, Shimizu Hiroki, Akaike Hidenori, Hosomura Naohiro, Kawaguchi Yoshihiko, Amemiya Hidetake, Kawaida Hiromichi, Sudo Makoto, Inoue Shingo, Kono Hiroshi, Ichikawa Daisuke

机构信息

First Department of Surgery, Faculty of Medicine University of Yamanashi, Chuo, Japan.

Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.

出版信息

Anticancer Res. 2018 May;38(5):2717-2722. doi: 10.21873/anticanres.12513.

DOI:10.21873/anticanres.12513

PMID:29715091

Abstract

BACKGROUND/AIM: Several recent studies have suggested that podoplanin (PDPN) expression correlates with malignant potential in various types of cancers. We investigated the expression pattern of PDPN and its clinical significance in gastric cancer.

MATERIALS AND METHODS

We assessed the immunohistochemical expression of PDPN in 91 gastric cancer tissues of patients who underwent curative surgery and evaluated the relationship between the expression levels and clinicopathological factors.

RESULTS

The tumor cells themselves revealed no expression of PDPN. However, PDPN was expressed in spindle-shaped stromal cells surrounding tumors in certain cases. PDPN-positive stromal cells significantly correlated with a larger tumor, advanced T- and N-stages, and lymphatic and vascular invasion. Multivariate analysis indicated that PDPN expression in spindle-shaped stromal cells (p=0.030) as well as N-stage (p=0.023) are independent prognostic factors.

CONCLUSION

Our findings demonstrated the PDPN expression in spindle-shaped stromal cells of patients with gastric cancers has a prognostic significance. Intensive chemotherapy and close follow-up should be recommended for these patients.

摘要

背景/目的：最近的几项研究表明，血小板源性生长因子结合蛋白（PDPN）的表达与多种癌症的恶性潜能相关。我们研究了PDPN在胃癌中的表达模式及其临床意义。