Maruyama Suguru, Furuya Shinji, Shiraishi Kensuke, Shimizu Hiroki, Akaike Hidenori, Hosomura Naohiro, Kawaguchi Yoshihiko, Amemiya Hidetake, Kawaida Hiromichi, Sudo Makoto, Inoue Shingo, Kono Hiroshi, Ichikawa Daisuke
First Department of Surgery, Faculty of Medicine University of Yamanashi, Chuo, Japan.
Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Anticancer Res. 2018 May;38(5):2717-2722. doi: 10.21873/anticanres.12513.
BACKGROUND/AIM: Several recent studies have suggested that podoplanin (PDPN) expression correlates with malignant potential in various types of cancers. We investigated the expression pattern of PDPN and its clinical significance in gastric cancer.
We assessed the immunohistochemical expression of PDPN in 91 gastric cancer tissues of patients who underwent curative surgery and evaluated the relationship between the expression levels and clinicopathological factors.
The tumor cells themselves revealed no expression of PDPN. However, PDPN was expressed in spindle-shaped stromal cells surrounding tumors in certain cases. PDPN-positive stromal cells significantly correlated with a larger tumor, advanced T- and N-stages, and lymphatic and vascular invasion. Multivariate analysis indicated that PDPN expression in spindle-shaped stromal cells (p=0.030) as well as N-stage (p=0.023) are independent prognostic factors.
Our findings demonstrated the PDPN expression in spindle-shaped stromal cells of patients with gastric cancers has a prognostic significance. Intensive chemotherapy and close follow-up should be recommended for these patients.
背景/目的：最近的几项研究表明，血小板源性生长因子结合蛋白（PDPN）的表达与多种癌症的恶性潜能相关。我们研究了PDPN在胃癌中的表达模式及其临床意义。
我们评估了91例接受根治性手术的胃癌患者组织中PDPN的免疫组化表达，并评估了表达水平与临床病理因素之间的关系。
肿瘤细胞本身未显示PDPN表达。然而，在某些情况下，PDPN在肿瘤周围的梭形基质细胞中表达。PDPN阳性基质细胞与较大的肿瘤、晚期T和N分期以及淋巴和血管侵犯显著相关。多因素分析表明，梭形基质细胞中的PDPN表达（p=0.030）以及N分期（p=0.023）是独立的预后因素。
我们的研究结果表明，胃癌患者梭形基质细胞中的PDPN表达具有预后意义。建议对这些患者进行强化化疗和密切随访。
