Hirayama Kazuyoshi, Kono Hiroshi, Nakata Yuuki, Akazawa Yoshihiro, Wakana Hiroyuki, Fukushima Hisataka, Fujii Hideki
First Department of Surgery, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan.
Surg Today. 2018 Jan;48(1):110-118. doi: 10.1007/s00595-017-1559-x. Epub 2017 Jul 12.
To investigate the role of podoplanin (PDPN) expression in invasive ductal carcinoma of the pancreas (IDCP) in humans.
Tumor samples were obtained from 95 patients with IDCP. Immunohistochemical staining was done to evaluate the expression of PDPN in cancer tissues.
PDPN was detected predominantly in stromal fibroblasts, stained with α-smooth muscle actin. The cutoff value of PDPN-positive areas was calculated according to a histogram. There was no significant difference in clinicopathologic factors between patients with high vs. those with low PDPN expression. The high PDPN group showed significantly poorer disease-free and disease-specific survival rates than the low PDPN group. Among patients from the high PDPN group, those with lymph node metastases and those with a tumor larger than 20 cm in diameter had significantly poorer prognoses than similar patients from the low PDPN group. Multivariate Cox proportional hazards analysis indicated that a high expression of PDPN was an independent risk factor for disease-specific survival.
PDPN expression in cancer-related fibrotic tissues is associated with a poor prognosis, especially in patients with large tumors or lymph node metastases.
研究足板蛋白（PDPN）表达在人类胰腺浸润性导管癌（IDCP）中的作用。
从95例IDCP患者获取肿瘤样本。进行免疫组织化学染色以评估癌组织中PDPN的表达。
PDPN主要在与α平滑肌肌动蛋白染色的基质成纤维细胞中检测到。根据直方图计算PDPN阳性区域的临界值。PDPN高表达患者与低表达患者之间的临床病理因素无显著差异。PDPN高表达组的无病生存率和疾病特异性生存率显著低于PDPN低表达组。在PDPN高表达组患者中，有淋巴结转移和肿瘤直径大于20 cm的患者的预后明显比PDPN低表达组的类似患者差。多变量Cox比例风险分析表明，PDPN高表达是疾病特异性生存的独立危险因素。
癌相关纤维化组织中的PDPN表达与预后不良相关，尤其是在肿瘤较大或有淋巴结转移的患者中。
