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由于开展了16年的抗丝虫病活动（2001 - 2016年），缅甸流行地区在消除淋巴丝虫病方面取得了快速进展。

Rapid progress towards elimination of lymphatic filariasis in endemic regions of Myanmar as a result of 16 years of anti-filarial activities (2001-2016).

作者信息

Win Kyawt Mon, Tripathy Jaya Prasad, Maung Thae Maung, Oo Tin, Thi Aung, Lon Khin Nan, Lin Zaw

机构信息

Vector Borne Diseases Control Program, Ministry of Health and Sports, Naypyitaw, Myanmar.

2International Union Against Tuberculosis and Lung Disease, The Union South-East Asia Regional Office, New Delhi, India.

出版信息

Trop Med Health. 2018 Apr 16;46:14. doi: 10.1186/s41182-018-0093-x. eCollection 2018.

DOI:10.1186/s41182-018-0093-x
PMID:29720887
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5916724/
Abstract

BACKGROUND

As Myanmar progresses towards lymphatic filariasis (LF) elimination, it is important to know how well the anti-filarial activities have performed. The present study was conducted to study the implementation of the key anti-filarial activities and their impact on key indicators of LF transmission.

METHODS

A secondary analysis of aggregate program data on the anti-filarial activities was conducted in four endemic state/regions of Myanmar receiving at least six mass drug administration (MDA) rounds during 2001-2016.

RESULTS

MDA coverage has been expanded to cover all the endemic implementation units (IUs), i.e., 45 by 2015 and 6 IUs out of them have already stopped MDA. The reported coverage of MDA ranges from 87 to 100% whereas surveyed coverage ranges from 78 to 100% among the eligible population. The prevalence of microfilaria has significantly declined especially in Magway from 4.7 to 0.2% and Sagaing region from 7.9 to 1.3% during 2001-2016. Around 2.5% of estimated cases of hydrocele were reported to the program during 2009-2014.

CONCLUSION

Myanmar has achieved significant success in interrupting LF transmission through several MDA rounds with high coverage. However, morbidity reporting and management, being in its initial phase requires an active surveillance system for identifying and managing people with LF-associated morbidities under the program.

摘要

背景

随着缅甸朝着消除淋巴丝虫病（LF）迈进，了解抗丝虫病活动的执行情况非常重要。本研究旨在探讨关键抗丝虫病活动的实施情况及其对淋巴丝虫病传播关键指标的影响。

方法

对缅甸四个流行邦/地区2001 - 2016年期间接受至少六轮大规模药物治疗（MDA）的抗丝虫病活动的汇总项目数据进行二次分析。

结果

MDA覆盖范围已扩大到所有流行实施单位（IU），即到2015年有45个，其中6个IU已停止MDA。报告的MDA覆盖率在87%至100%之间，而在符合条件的人群中，调查覆盖率在78%至100%之间。在2001 - 2016年期间，微丝蚴血症的患病率显著下降，尤其是在马圭地区从4.7%降至0.2%，实皆地区从7.9%降至1.3%。在2009 - 2014年期间，约2.5%的估计鞘膜积液病例报告给了该项目。

结论

缅甸通过几轮高覆盖率的MDA在中断淋巴丝虫病传播方面取得了显著成功。然而，发病率报告和管理尚处于初始阶段，需要一个积极的监测系统来识别和管理该项目下患有淋巴丝虫病相关疾病的人群。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b89e/5916724/ad10933f002e/41182_2018_93_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b89e/5916724/45d42e5a3554/41182_2018_93_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b89e/5916724/551dd5c69837/41182_2018_93_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b89e/5916724/84c9ebf26d64/41182_2018_93_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b89e/5916724/473d8fd4ccc1/41182_2018_93_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b89e/5916724/ad10933f002e/41182_2018_93_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b89e/5916724/45d42e5a3554/41182_2018_93_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b89e/5916724/551dd5c69837/41182_2018_93_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b89e/5916724/84c9ebf26d64/41182_2018_93_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b89e/5916724/473d8fd4ccc1/41182_2018_93_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b89e/5916724/ad10933f002e/41182_2018_93_Fig5_HTML.jpg

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