Lunglmayr G, Girsch E, Meixner E M, Viehberger G, Bieglmayer C
Department of Urology, Mistelbach General Infirmary, Austria.
Urol Res. 1988;16(4):315-9. doi: 10.1007/BF00263642.
The effects of long term GnRH treatment with the biodegradable depot formulation of ICI 118.630 on hormone levels and spermatogenesis were investigated in 18 males with advanced prostate cancer. Plasma levels of FSH, LH, testosterone, DHEA-S and SHBG were monitored at regular intervals. The drug suppressed FSH, LH and testosterone significantly and did not affect DHEA-S and SHBG plasma levels. Tissue specimens for histologic assessment and quantitative analysis of germinal cell types were obtained at secondary orchidectomy in 16 patients immediately following GnRH analogue treatment. Germinal cell maturation was arrested at the spermatogonial stage. In two patients discontinuing treatment histologic assessment of secondary orchidectomy specimens 9 and 10 months after the last GnRH analogue depot injection resulted in germinal cell maturation to late spermatids in part of the tubule cross sections. These results indicate that long term administration of the GnRH analogue fails to produce complete testicular sclerosis and spermatogenic arrest might be reversible.
在18例晚期前列腺癌男性患者中，研究了使用可生物降解长效剂型的ICI 118.630长期进行促性腺激素释放激素（GnRH）治疗对激素水平和精子发生的影响。定期监测促卵泡生成素（FSH）、促黄体生成素（LH）、睾酮、硫酸脱氢表雄酮（DHEA-S）和性激素结合球蛋白（SHBG）的血浆水平。该药物显著抑制FSH、LH和睾酮，且不影响DHEA-S和SHBG的血浆水平。在16例患者接受GnRH类似物治疗后立即进行二次睾丸切除时，获取组织标本用于组织学评估和生殖细胞类型的定量分析。生殖细胞成熟停滞在精原细胞阶段。在2例停止治疗的患者中，末次GnRH类似物长效注射后9个月和10个月进行二次睾丸切除标本的组织学评估，结果显示部分小管横切面中的生殖细胞成熟至晚期精子细胞。这些结果表明，长期给予GnRH类似物不会导致完全的睾丸硬化，精子发生停滞可能是可逆的。
