Johansen T E, Ogreid P, Kjellevold K, Blom P
Department of Urology, Akershus Central Hospital, Nordbyhagen, Norway.
Br J Urol. 1990 Apr;65(4):376-8. doi: 10.1111/j.1464-410x.1990.tb14759.x.
Orchiectomy was performed in 16 patients because of progression of prostatic cancer despite adequate medical castration with goserelin (Zoladex, ICI) over a mean period of 17.6 months. Severe tubular atrophy was seen in the testes. The Leydig cells also showed signs of atrophy, a fact that may indicate a direct effect of goserelin on these cells. In 1 patient, however, orchiectomy was postponed for 3 months after cessation of medical castration. The serum testosterone had resumed almost normal values and testicular histology revealed intact spermatogenesis and apparently normal Leydig cells.
16例患者因前列腺癌进展接受了睾丸切除术，尽管使用戈舍瑞林（诺雷德，帝国化学工业公司）进行了平均17.6个月的充分药物去势治疗。睾丸出现严重的小管萎缩。睾丸间质细胞也显示出萎缩迹象，这可能表明戈舍瑞林对这些细胞有直接作用。然而，1例患者在药物去势停止后，睾丸切除术推迟了3个月。血清睾酮已恢复到几乎正常的值，睾丸组织学显示生精功能完整，睾丸间质细胞明显正常。
