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维甲酸信号通路在海星变态发育中的作用。

The role of retinoic acid signaling in starfish metamorphosis.

作者信息

Yamakawa Shumpei, Morino Yoshiaki, Honda Masanao, Wada Hiroshi

机构信息

Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8572 Japan.

出版信息

Evodevo. 2018 Apr 21;9:10. doi: 10.1186/s13227-018-0098-x. eCollection 2018.

DOI:10.1186/s13227-018-0098-x
PMID:29721256
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5910596/
Abstract

BACKGROUND

Although retinoic acid (RA) signaling plays a crucial role in the body patterning of chordates, its function in non-chordate invertebrates, other than its mediation of environmental cues triggering metamorphosis in cnidarians, is largely unknown. We investigated the role of RA signaling in the metamorphosis of starfish (Echinodermata).

RESULTS

We found that exogenous RA treatment induced metamorphosis in starfish larvae. In contrast, inhibitors of RA synthesis and RA receptors suppressed metamorphosis triggered by attachment to a substrate. Gene expressions of the RA signaling component were detected in competent larvae.

CONCLUSIONS

This study provides insight into the ancestral function of RA signaling, which is conserved in the metamorphosis of cnidarians and starfish.

摘要

背景

尽管视黄酸（RA）信号通路在脊索动物的身体模式形成中起着关键作用，但其在非脊索动物中的功能，除了在刺胞动物中介导触发变态的环境线索外，很大程度上尚不清楚。我们研究了RA信号通路在海星（棘皮动物门）变态中的作用。

结果

我们发现外源性RA处理可诱导海星幼虫变态。相反，RA合成抑制剂和RA受体抑制剂可抑制因附着于基质而触发的变态。在有能力的幼虫中检测到RA信号通路成分的基因表达。

结论

本研究深入了解了RA信号通路的原始功能，该功能在刺胞动物和海星的变态中是保守的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f796/5910596/b71c3d205f94/13227_2018_98_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f796/5910596/6b995e3916b6/13227_2018_98_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f796/5910596/04715a835ecf/13227_2018_98_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f796/5910596/5de471346b0c/13227_2018_98_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f796/5910596/f0c76244f463/13227_2018_98_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f796/5910596/4d1251ad7520/13227_2018_98_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f796/5910596/b71c3d205f94/13227_2018_98_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f796/5910596/6b995e3916b6/13227_2018_98_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f796/5910596/04715a835ecf/13227_2018_98_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f796/5910596/5de471346b0c/13227_2018_98_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f796/5910596/f0c76244f463/13227_2018_98_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f796/5910596/4d1251ad7520/13227_2018_98_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f796/5910596/b71c3d205f94/13227_2018_98_Fig6_HTML.jpg

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