Valderrábano Rodrigo J, Linares Maria I
University of Miami Miller School of Medicine, Dominion Tower 1400 NW 10th Ave, Ste. 805A, Miami, FL 33136 USA.
Clin Diabetes Endocrinol. 2018 Apr 25;4:9. doi: 10.1186/s40842-018-0060-9. eCollection 2018.
Skeletal fractures can result when there are co-morbid conditions that negatively impact bone strength. Fractures represent an important source of morbidity and mortality, especially in older populations. Diabetes mellitus is a metabolic disorder that has reached worldwide epidemic proportions and is increasingly being recognized as a risk factor for fracture. Type 1 and Type 2 diabetes have different effects on bone mineral density but share common pathways, which lead to bone fragility. In this review, we discuss the available data on diabetes and fractures, bone density and the clinical implications for fracture risk stratification in current practice.
当存在对骨强度产生负面影响的合并症时，可能会导致骨骼骨折。骨折是发病和死亡的重要原因，尤其是在老年人群中。糖尿病是一种代谢紊乱疾病，已在全球范围内流行，并且越来越被认为是骨折的一个危险因素。1型糖尿病和2型糖尿病对骨密度有不同影响，但有共同的途径，这些途径会导致骨脆性增加。在本综述中，我们讨论了关于糖尿病与骨折、骨密度以及当前实践中骨折风险分层的临床意义的现有数据。
