Cullberg G, Mattsson L A
Department of Obstetrics and Gynecology, University of Gothenburg, East Hospital, Sweden.
Acta Obstet Gynecol Scand. 1988;67(2):167-9. doi: 10.3109/00016348809004192.
Nineteen fertile women were treated with three differently composed oral contraceptives in a cross-over study and were randomly allocated to begin with one of the three preparations. The tablets contained 0.030 mg ethinylestradiol +0.15 mg desogestrel alone (A) or in combination with either 0.5 mg estriol (B) or 2 mg estriol (C). After two treatment cycles on each preparation, blood samples were obtained and analysed for ceruloplasmin, SHBG, prealbumin, transcortin and thyroxine-binding globulin. No differences were found in the induction of liver protein synthesis. It was concluded that the addition of estriol in doses of 0.5 or 2 mg did not influence the effects induced by ethinylestradiol.
在一项交叉研究中，19名育龄妇女接受了三种成分不同的口服避孕药治疗，并被随机分配从三种制剂中的一种开始服用。这些片剂单独含有0.030毫克乙炔雌二醇+0.15毫克去氧孕烯（A），或与0.5毫克雌三醇（B）或2毫克雌三醇（C）联合使用。在每种制剂进行两个治疗周期后，采集血样并分析铜蓝蛋白、性激素结合球蛋白、前白蛋白、皮质素转运蛋白和甲状腺素结合球蛋白。在肝脏蛋白质合成的诱导方面未发现差异。得出的结论是，添加0.5毫克或2毫克剂量的雌三醇不会影响乙炔雌二醇诱导的效果。
