MCT1 杂合不足对小鼠视网膜的影响。
Impact of MCT1 Haploinsufficiency on the Mouse Retina.
机构信息
Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA.
Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA.
出版信息
Adv Exp Med Biol. 2018;1074:375-380. doi: 10.1007/978-3-319-75402-4_46.
Abstract
The monocarboxylate transporter 1 (MCT1) is highly expressed in the outer retina, suggesting that it plays a critical role in photoreceptors. We examined MCT1 heterozygotes, which express half of the normal complement of MCT1. The MCT1 retina developed normally and retained normal function, indicating that MCT1 is expressed at sufficient levels to support outer retinal metabolism.
摘要
单羧酸转运蛋白 1（MCT1）在外网状层中高度表达，表明其在光感受器中发挥着关键作用。我们研究了 MCT1 杂合子，它们表达正常 MCT1 一半的蛋白。MCT1 视网膜正常发育并保持正常功能，表明 MCT1 的表达水平足以支持外网状层代谢。
Zotero 插件