College of Chemistry, Jilin University, Changchun, 130012, P. R. China.
Department of Technical Center, Jilin Entry Exit Inspection and Quarantine Bureau, Changchun, 130033, P. R. China.
Chemistry. 2018 Jul 20;24(41):10390-10396. doi: 10.1002/chem.201800092. Epub 2018 Jun 27.
A solid-phase extraction adsorbent based on an aptamer-functionalized magnetic conjugated organic framework (COF) was developed for selective extraction of traces of hydroxylated polychlorinated biphenyls. This material has advantages such as superparamagnetism of the magnetic core, high surface area and porous structure of the COF, and high specific affinity of the aptamer. In combination with HPLC-MS, the aptamer-functionalized magnetic COF was used for the capture of hydroxy-2',3',4',5,5'-pentachlorobiphenyl in human serum. The method provided a linear range of 0.01-40 ng mL with a good correlation coefficient (R =0.9973). The limit of detection was as low as 2.1 pg mL . Furthermore, the material showed good reusability and could be applied in at least ten extraction cycles with recoveries greater than 90 %.
基于适配体功能化的磁性共轭有机骨架（COF）的固相萃取吸附剂被开发出来，用于选择性萃取痕量的羟基多氯联苯。该材料具有磁性核的超顺磁性、COF 的高表面积和多孔结构以及适配体的高特异性亲和力等优点。结合高效液相色谱-质谱法，将适配体功能化的磁性 COF 用于人血清中羟基-2'，3'，4'，5，5'-五氯联苯的捕获。该方法提供了 0.01-40ngmL 的线性范围，具有良好的相关系数（R=0.9973）。检测限低至 2.1pgmL。此外，该材料表现出良好的可重复使用性，在至少十个萃取循环中仍具有大于 90%的回收率。
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