慢性阻塞性肺疾病（COPD）患者带状疱疹的风险和影响：一项基于人群的研究，2009-2014 年。
Risk and impact of herpes zoster among COPD patients: a population-based study, 2009-2014.
机构信息
Vaccine Research. Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, FISABIO-Public Health, Valencia, Spain.
Vaccine Research Area, FISABIO-Public Health, Avda. Cataluña, 21, 46020, Valencia, Spain.
出版信息
BMC Infect Dis. 2018 May 3;18(1):203. doi: 10.1186/s12879-018-3121-x.
BACKGROUND
The objective of this study was to assess the incidence of Herpes Zoster (HZ) among patients with chronic obstructive pulmonary disease (COPD) and the impact of HZ on the underlying COPD.
METHODS
A retrospective cohort of all subjects older than 49 years was followed up between 2009 and 2014 using population and health databases of Valencia Region (Spain). HZ and COPD were identified using ICD-9 codes, differentiating COPD patients with inhaled corticosteroids prescriptions (COPD-ICS). The incidence of HZ was compared among 3 groups [non-COPD, COPD and COPD-ICS populations] and use of healthcare resource due to HZ for 6 months following HZ diagnosis through different statistical generalized linear models (GLM). We also compared resources consumption due to COPD before and after HZ.
RESULTS
The cohort consisted of 2,289,485 subjects, including 161,317 COPD patients of which 29,708 were COPD-ICS. HZ incidence rates were 11 (95% confidence interval [CI]: 10.7-11.4) and 13 (95% CI: 12.3-13.8) cases/1000 persons-year for COPD and COPD-ICS populations respectively. Incidence increased with age in all groups. The risk of HZ rose by 45 and 61% among COPD and COPD-ICS patients respectively compared to non-COPD (95% credible intervals [CrI]: 1.41-1.5 and 1.52-1.71 respectively). COPD patients consumed more resources due to their HZ than non-COPD. There was no statistically significant impact of the HZ on the resources consumed due to COPD during the 6 months post-HZ compared to the 6 months pre-HZ.
CONCLUSIONS
The presence of COPD increases the risk, severity and impact of zoster episodes.
背景
本研究旨在评估慢性阻塞性肺疾病（COPD）患者中带状疱疹（HZ）的发病率以及 HZ 对基础 COPD 的影响。
方法
使用西班牙瓦伦西亚地区的人口和健康数据库，对 2009 年至 2014 年间所有年龄大于 49 岁的患者进行回顾性队列研究。使用 ICD-9 编码识别 HZ 和 COPD，区分有吸入皮质类固醇处方的 COPD 患者（COPD-ICS）。在非 COPD、COPD 和 COPD-ICS 人群中比较 HZ 的发病率，并通过不同的统计广义线性模型（GLM）比较 HZ 诊断后 6 个月内因 HZ 而使用医疗资源的情况。我们还比较了 HZ 前后因 COPD 而导致的资源消耗。
结果
该队列包括 2289485 名患者，其中包括 161317 名 COPD 患者，其中 29708 名患者为 COPD-ICS。COPD 和 COPD-ICS 人群的 HZ 发病率分别为 11（95%置信区间[CI]：10.7-11.4）和 13（95% CI：12.3-13.8）例/1000 人年。在所有组中，发病率随年龄增长而增加。与非 COPD 患者相比，COPD 和 COPD-ICS 患者的 HZ 风险分别增加了 45%和 61%（95%可信区间[CrI]：1.41-1.5 和 1.52-1.71）。与非 COPD 患者相比，COPD 患者因 HZ 而消耗的资源更多。与 HZ 前 6 个月相比，HZ 后 6 个月 COPD 患者因 COPD 而消耗的资源并无统计学意义的显著影响。
结论
COPD 的存在增加了带状疱疹发作的风险、严重程度和影响。
Zotero 插件