Zhang Hong, Luo Yan-Ping, Cao Ze-Yu, Zhang Xin-Zhuang, Cao Liang, Wang Zhen-Zhong, Xiao Wei
Jiangsu Kanion Parmaceutical Co., Ltd., Lianyungang 222001, China.
State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China.
Zhongguo Zhong Yao Za Zhi. 2018 Apr;43(7):1410-1415. doi: 10.19540/j.cnki.cjcmm.20180312.005.
To investigate the best active compatibility of ginkgolide A, B and K (GA，GB，GK). The effects of GA, GB, GK alone, combinations of each two of them, and combinations of these three components on platelet-activating factor (PAF)-induced platelet aggregation activity and rat cerebral ischemia reperfusion model (tMCAO) were compared in this study. Different compatibilities of GA, GB and GK could significantly reduce the maximum aggregation rate of PAF-induced platelet aggregation, and the effect was most obvious in combination of the three. Different compatibilities of GA, GB and GK could alleviate the neural function, cerebral infarction volume and cerebral edema in the tMCAO model of rats to different degrees, and the effect of combinations of the three was stronger than those of combinations of two and single use. The combination of all of GA, GB and GK had the strongest effect on nerve injury caused by anti-platelet aggregation in tMCAO rats.
为研究银杏内酯A、B、K（GA、GB、GK）的最佳活性配伍。本研究比较了GA、GB、GK单独使用、两两组合以及三者组合对血小板活化因子（PAF）诱导的血小板聚集活性和大鼠脑缺血再灌注模型（tMCAO）的影响。GA、GB和GK的不同配伍均可显著降低PAF诱导的血小板聚集的最大聚集率，且三者组合效果最明显。GA、GB和GK的不同配伍可不同程度减轻tMCAO大鼠模型的神经功能缺损、脑梗死体积和脑水肿，三者组合的效果强于两两组合及单独使用。GA、GB和GK三者组合对tMCAO大鼠抗血小板聚集所致神经损伤的作用最强。
