原发性肿瘤切除对伴有同步多灶性肝转移的胰腺神经内分泌肿瘤的预后影响。
The prognostic impact of primary tumor resection in pancreatic neuroendocrine tumors with synchronous multifocal liver metastases.
作者信息
Lin Chen, Dai Hongmei, Hong Xiafei, Pang Haiyu, Wang Xianze, Xu Peiran, Jiang Jialin, Wu Wenming, Zhao Yupei
机构信息
Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Shuaifuyuan Wangfujing, Beijing 100730, China.
Central Research Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Clinical Epidemiology Unit, International Epidemiology Network, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Shuaifuyuan Wangfujing, Beijing 100730, China.
出版信息
Pancreatology. 2018 Jul;18(5):608-614. doi: 10.1016/j.pan.2018.04.014. Epub 2018 Apr 30.
BACKGROUND
Whether primary tumor resection benefits patients with synchronous multifocal liver metastases from pancreatic neuroendocrine tumors remains controversial. We investigated whether primary tumor resection significantly affects survival in this study.
METHODS
A retrospective study of patients with synchronous multifocal liver metastases from pancreatic neuroendocrine tumors between 1998 and 2016 was performed. Patient demographics, operation details, adjuvant treatment, and pathological and survival information were collected, and relevant clinical-pathological parameters were assessed in univariate and multivariate survival analyses.
RESULTS
Sixty-three patients were included in this study, including 35 who underwent primary tumor resection. The median survival time and 5-year survival rate of this cohort were 50 months and 44.5%, respectively. Median survival time in the resected group was significantly longer at 72 months than that of 32 months in the nonresected group (p = 0.010). Multivariate analysis showed that primary tumor surgery was a significant independent prognostic factor (HR 0.312, 95% CI: 0.128-0.762, p = 0.011).
CONCLUSIONS
Primary tumor resection significantly benefits patients with synchronous multifocal liver metastases from pancreatic neuroendocrine tumors.
背景
原发性肿瘤切除对患有胰腺神经内分泌肿瘤同步多灶性肝转移的患者是否有益仍存在争议。在本研究中，我们调查了原发性肿瘤切除是否会显著影响患者的生存率。
方法
对1998年至2016年间患有胰腺神经内分泌肿瘤同步多灶性肝转移的患者进行了一项回顾性研究。收集了患者的人口统计学资料、手术细节、辅助治疗以及病理和生存信息，并在单因素和多因素生存分析中评估了相关的临床病理参数。
结果
本研究共纳入63例患者，其中35例接受了原发性肿瘤切除。该队列的中位生存时间和5年生存率分别为50个月和44.5%。切除组的中位生存时间明显更长，为72个月，而非切除组为32个月（p = 0.010）。多因素分析表明，原发性肿瘤手术是一个显著的独立预后因素（HR 0.312，95% CI：0.128 - 0.762，p = 0.011）。
结论
原发性肿瘤切除对患有胰腺神经内分泌肿瘤同步多灶性肝转移的患者有显著益处。
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