Vermeulen-Meiners C, Poortman J, Nabuurs M, Thijssen J H
Department of Obstetrics and Gynecology, University of Utrecht, The Netherlands.
Gynecol Endocrinol. 1988 Jun;2(2):121-30. doi: 10.3109/09513598809023620.
The endogenous concentrations of testosterone (Testo), androstenedione (Adion), 5-androstene-3 beta, 17 beta-diol (Adiol), dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) have been measured in endometrium, myometrium and vagina from 23 premenopausal women at different stages of the cycle. The tissue to plasma gradient was positive for all androgens except DHEAS; a significant correlation existed between plasma and tissue levels of Adiol and DHEAS. In all tissues significant correlations were calculated between Adiol and DHEA, Adion and Testo, and Adiol and DHEAS. Except for Testo, androgen concentrations were different in the tissues with a significant correlation between the tissues, each tissue seeming to be able to create its own specific intratissue androgen pattern. During the cycle Testo was highest in myometrium and vagina and Adion in myometrium and endometrium during the secretory phase. Except for DHEA, androgens were preferentially localized in the cytosol fraction of the cells. From this localization and the known inhibitory effects of androgens on the activity of estrogen metabolizing enzymes, it is postulated that androgens play a role in enzymatic rather than receptor-mediated processes in uterine cells.
已对23名处于月经周期不同阶段的绝经前女性的子宫内膜、子宫肌层和阴道中睾酮（Testo）、雄烯二酮（Adion）、5-雄烯-3β，17β-二醇（Adiol）、脱氢表雄酮（DHEA）和硫酸脱氢表雄酮（DHEAS）的内源性浓度进行了测量。除DHEAS外，所有雄激素的组织与血浆梯度均为正值；Adiol和DHEAS的血浆与组织水平之间存在显著相关性。在所有组织中，均计算出Adiol与DHEA、Adion与Testo以及Adiol与DHEAS之间存在显著相关性。除Testo外，各组织中的雄激素浓度不同，组织之间存在显著相关性，每个组织似乎都能够形成自身特定的组织内雄激素模式。在月经周期中，Testo在子宫肌层和阴道中最高，Adion在分泌期的子宫肌层和子宫内膜中最高。除DHEA外，雄激素优先定位于细胞的胞质溶胶部分。根据这种定位以及雄激素对雌激素代谢酶活性的已知抑制作用，推测雄激素在子宫细胞的酶促过程而非受体介导过程中发挥作用。
