Telfeian Albert Edward
Department of Neurosurgery, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
J Spine Surg. 2018 Mar;4(1):162-166. doi: 10.21037/jss.2018.03.08.
One complication associated with recombinant human bone morphogenetic protein (rhBMP-2) use in minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) is heterotopic bone growth at the neural foramen which results in the compression of neural structures. Here we present an awake, minimally invasive surgical approach for treating the radiculopathy that results from this excessive bone growth in the foramen. A 42-year-old male underwent a lumbar 4-sacral 1 MIS-TLIF by another surgeon. He did well in the initial postoperative period, but he began to note right leg pain and numbness in an L5 dermatomal pattern. The pain continued for 2 years despite interventional pain management, and he began to note left foot dorsiflexion weakness. An electromyography (EMG) showed a left L5 radiculopathy and a CT Lumbar spine demonstrated excessive bone growth in the right L4-5 neural foramen. The patient underwent an awake, endoscopic foraminotomy procedure utilizing a blunt tipped manual shaver drill system. The patient's radicular symptoms improved immediately, and he remained asymptomatic at the 1 year follow up. Heterotopic foraminal bone growth is one potential complication of rhBMP-2 use in the MIS-TLIF procedure. The endoscopic procedure described here is a minimally invasive surgical option that can be performed in an awake patient and is suggested a unique salvage or rescue procedure to be considered for the treatment of this potential rhBMP-2 complication.
在微创经椎间孔腰椎椎间融合术(MIS-TLIF)中使用重组人骨形态发生蛋白(rhBMP-2)的一个并发症是神经孔处异位骨生长,这会导致神经结构受压。在此,我们介绍一种清醒状态下的微创手术方法,用于治疗因神经孔处这种过度骨生长导致的神经根病。一名42岁男性由另一位外科医生进行了腰4至骶1的MIS-TLIF手术。术后初期他恢复良好,但他开始注意到出现L5皮节模式的右腿疼痛和麻木。尽管进行了介入性疼痛管理,疼痛仍持续了2年,并且他开始注意到左脚背屈无力。肌电图(EMG)显示左L5神经根病,腰椎CT显示右L4 - 5神经孔处有过度骨生长。该患者接受了使用钝头手动刨削钻系统的清醒状态下的内镜下椎间孔切开术。患者的神经根症状立即得到改善,在1年随访时仍无症状。异位椎间孔骨生长是MIS-TLIF手术中使用rhBMP-2的一种潜在并发症。这里描述的内镜手术是一种微创外科选择,可以在清醒患者身上进行,并且被认为是一种独特的补救或挽救手术,可用于治疗这种潜在的rhBMP-2并发症。