Gardiner S M, Compton A M, Bennett T
Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Nottingham, United Kingdom.
Am J Physiol. 1988 Nov;255(5 Pt 2):R737-43. doi: 10.1152/ajpregu.1988.255.5.R737.
The regional hemodynamic effects of rat atrial natriuretic peptide (ANP) (1 and 10 nmol) were measured in the same conscious Brattleboro rats in water-replete and in water-deprived states (14 h). In the latter condition, the effects of ANP were compared with those of captopril (3.2 mumol). In rats in the water-replete state, the low dose of ANP had no significant effects on mean arterial pressure (MAP) or renal, superior mesenteric, or hindquarter vascular resistances, although heart rate (HR) showed a transient increase. The high dose of ANP caused a fall in MAP and an increase in HR. Renal and hindquarter vascular beds showed dilatation followed by constriction; there was a mesenteric vasoconstriction only. In rats in the water-deprived state, the low dose of ANP caused a marked fall in MAP but only a transient increase in HR; there was marked hindquarters vasodilation. The high dose of ANP caused dramatic hypotension and bradyarrhythmia; an initial hindquarter vasodilation gave way to vasoconstriction; renal and mesenteric vasoconstrictions also occurred. The initial effects of captopril on MAP were similar to those of the high dose of ANP, but the regional hemodynamic effects of captopril indicated a potent inhibition of both primary and secondary vasoconstrictor mechanisms.
在水负荷充足和缺水状态（14小时）下，对同一只清醒的Brattleboro大鼠测量大鼠心房利钠肽（ANP）（1和10纳摩尔）的局部血流动力学效应。在缺水状态下，将ANP的效应与卡托普利（3.2微摩尔）的效应进行比较。在水负荷充足的大鼠中，低剂量的ANP对平均动脉压（MAP）或肾、肠系膜上或后肢血管阻力无显著影响，尽管心率（HR）有短暂增加。高剂量的ANP导致MAP下降和HR增加。肾和后肢血管床先扩张后收缩；仅肠系膜血管收缩。在缺水状态下的大鼠中，低剂量的ANP导致MAP显著下降，但HR仅短暂增加；后肢有明显的血管舒张。高剂量的ANP导致严重的低血压和心律失常；最初的后肢血管舒张被血管收缩所取代；肾和肠系膜血管也发生收缩。卡托普利对MAP的初始效应与高剂量的ANP相似，但卡托普利的局部血流动力学效应表明其对原发性和继发性血管收缩机制均有强力抑制作用。
