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姜黄对氯化铈致小鼠神经行为和神经化学损伤的保护作用。

Protective effects of Curcuma longa against neurobehavioral and neurochemical damage caused by cerium chloride in mice.

机构信息

Laboratory of Animal Ecophysiology, Faculty of Life Sciences, University of Sfax, Sfax, Tunisia.

Department of Biology, Faculty of Science and Arts - Khulais, University of Jeddah, Jeddah, Saudi Arabia.

出版信息

Environ Sci Pollut Res Int. 2018 Jul;25(20):19555-19565. doi: 10.1007/s11356-018-2151-7. Epub 2018 May 7.

Abstract

Cerium chloride (CeCl) is considered an environmental pollutant and a potent neurotoxic agent. Medicinal plants have many bioactive compounds that provide protection against damage caused by such pollutants. Curcuma longa is a bioactive compound-rich plant with very important antioxidant properties. To study the preventive and healing effects of Curcuma longa on cerium-damaged mouse brains, we intraperitoneally injected cerium chloride (CeCl, 20 mg/kg BW) along with Curcuma longa extract, administrated by gavage (100 mg/kg BW), into mice for 60 days. We then examined mouse behavior, brain tissue damage, and brain oxidative stress parameters. Our results revealed a significant modification in the behavior of the CeCl-treated mice. In addition, CeCl induced a significant increment in lipid peroxidation, carbonyl protein (PCO), and advanced oxidation protein product levels, as well as a significant reduction in superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities. Acetylcholinesterase (AChE) activity remarkably increased in the brain of CeCl-treated mice. Histopathological observations confirmed these results. Curcuma longa attenuated CeCl-induced oxidative stress and increased the activities of antioxidant enzymes. It also decreased AChE activity in the CeCl-damaged mouse brain that was confirmed by histopathology. In conclusion, this study suggests that Curcuma longa has a neuroprotective effect against CeCl-induced damage in the brain.

摘要

氯化铈(CeCl)被认为是一种环境污染物和强效神经毒性物质。药用植物含有许多生物活性化合物,可以防止此类污染物造成的损害。姜黄是一种生物活性化合物丰富的植物,具有非常重要的抗氧化特性。为了研究姜黄对铈损伤的小鼠大脑的预防和治疗作用,我们将氯化铈(CeCl,20mg/kgBW)腹腔内注射,并同时灌胃姜黄提取物(100mg/kgBW),持续 60 天。然后,我们检查了小鼠的行为、脑组织损伤和大脑氧化应激参数。我们的结果表明,CeCl 处理的小鼠的行为发生了显著变化。此外,CeCl 诱导脂质过氧化、羰基蛋白(PCO)和高级氧化蛋白产物水平显著增加,超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GPx)活性显著降低。乙酰胆碱酯酶(AChE)活性在 CeCl 处理的小鼠大脑中显著增加。组织病理学观察证实了这些结果。姜黄减轻了 CeCl 诱导的氧化应激,并增加了抗氧化酶的活性。它还降低了 CeCl 损伤的小鼠大脑中的 AChE 活性,这通过组织病理学得到了证实。总之,这项研究表明姜黄对 CeCl 诱导的大脑损伤具有神经保护作用。

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