Laboratory of Animal Ecophysiology, Faculty of Life Sciences, University of Sfax, Sfax, Tunisia.
Department of Biology, Faculty of Science and Arts - Khulais, University of Jeddah, Jeddah, Saudi Arabia.
Environ Sci Pollut Res Int. 2018 Jul;25(20):19555-19565. doi: 10.1007/s11356-018-2151-7. Epub 2018 May 7.
Cerium chloride (CeCl) is considered an environmental pollutant and a potent neurotoxic agent. Medicinal plants have many bioactive compounds that provide protection against damage caused by such pollutants. Curcuma longa is a bioactive compound-rich plant with very important antioxidant properties. To study the preventive and healing effects of Curcuma longa on cerium-damaged mouse brains, we intraperitoneally injected cerium chloride (CeCl, 20 mg/kg BW) along with Curcuma longa extract, administrated by gavage (100 mg/kg BW), into mice for 60 days. We then examined mouse behavior, brain tissue damage, and brain oxidative stress parameters. Our results revealed a significant modification in the behavior of the CeCl-treated mice. In addition, CeCl induced a significant increment in lipid peroxidation, carbonyl protein (PCO), and advanced oxidation protein product levels, as well as a significant reduction in superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities. Acetylcholinesterase (AChE) activity remarkably increased in the brain of CeCl-treated mice. Histopathological observations confirmed these results. Curcuma longa attenuated CeCl-induced oxidative stress and increased the activities of antioxidant enzymes. It also decreased AChE activity in the CeCl-damaged mouse brain that was confirmed by histopathology. In conclusion, this study suggests that Curcuma longa has a neuroprotective effect against CeCl-induced damage in the brain.
氯化铈(CeCl)被认为是一种环境污染物和强效神经毒性物质。药用植物含有许多生物活性化合物,可以防止此类污染物造成的损害。姜黄是一种生物活性化合物丰富的植物,具有非常重要的抗氧化特性。为了研究姜黄对铈损伤的小鼠大脑的预防和治疗作用,我们将氯化铈(CeCl,20mg/kgBW)腹腔内注射,并同时灌胃姜黄提取物(100mg/kgBW),持续 60 天。然后,我们检查了小鼠的行为、脑组织损伤和大脑氧化应激参数。我们的结果表明,CeCl 处理的小鼠的行为发生了显著变化。此外,CeCl 诱导脂质过氧化、羰基蛋白(PCO)和高级氧化蛋白产物水平显著增加,超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GPx)活性显著降低。乙酰胆碱酯酶(AChE)活性在 CeCl 处理的小鼠大脑中显著增加。组织病理学观察证实了这些结果。姜黄减轻了 CeCl 诱导的氧化应激,并增加了抗氧化酶的活性。它还降低了 CeCl 损伤的小鼠大脑中的 AChE 活性,这通过组织病理学得到了证实。总之,这项研究表明姜黄对 CeCl 诱导的大脑损伤具有神经保护作用。