Centro de Ciências Naturais e Exatas, Departamento de Química, Laboratório de Enzimologia Toxicológica, Universidade Federal de Santa Maria, Campus Universitário, Camobi, Brazil.
Cell Biochem Funct. 2011 Dec;29(8):703-7. doi: 10.1002/cbf.1804. Epub 2011 Sep 19.
With the evidence that curcumin may be a potent neuroprotective agent and that cigarette smoke is associated with a decline in the cognitive performance as our bases, we investigated the activities of Ecto-Nucleoside Triphosphate Diphosphohydrolase (NTPDase), 5'-nucleotidase and acetylcholinesterase (AChE) in cerebral cortex synaptosomes from cigarette smoke-exposed rats treated with curcumin (Cur). The experimental procedures entailed two sets of experiments. In the first set, the groups were vehicle, Cur 12·5, 25 and 50 mg·kg(-1) ; those in the second set were vehicle, smoke, smoke and Cur 12·5, 25 and 50 mg·kg(-1) . Curcumin prevented the increased NTPDase, 5'-nucleotidase and AChE activities caused by smoke exposure. We suggest that treatment with Cur was protective because the decrease of ATP and acetylcholine (ACh) concentrations is responsible for cognitive impairment, and both ATP and ACh have key roles in neurotransmission.
基于姜黄素可能是一种有效的神经保护剂，以及吸烟会导致认知能力下降的证据，我们研究了姜黄素（Cur）处理的暴露于香烟烟雾的大鼠大脑皮质突触体中的外核苷酸三磷酸二磷酸水解酶（NTPDase）、5'-核苷酸酶和乙酰胆碱酯酶（AChE）的活性。实验程序包括两组实验。在第一组中，实验组分别为载体、Cur12.5、25 和 50mg·kg(-1)；在第二组中，实验组分别为载体、烟雾、烟雾和 Cur12.5、25 和 50mg·kg(-1)。姜黄素可防止因吸烟引起的 NTPDase、5'-核苷酸酶和 AChE 活性增加。我们认为 Cur 的治疗具有保护作用，因为 ATP 和乙酰胆碱（ACh）浓度的降低与认知障碍有关，而 ATP 和 ACh 在神经传递中都起着关键作用。
