Duan Zhiqiang, Hu Shunlin, Liu Xiufan
Wei Sheng Wu Xue Bao. 2016 Jul 4;56(7):1079-88.
Recent studies have found that the matrix protein of paramyxoviruses is a multifunctional viral protein. In addition to inhibiting the transcription and translation of cell genes, regulating the replication and transcription of viral genome and recruiting cellular proteins to facilitate viral assembly and budding, the matrix protein can enhance the replication of paramyxoviruses through its ubiquitination and phosphorylation. However, as a member of paramyxoviruses, the matrix protein of Newcastle disease virus (NDV) is only demonstrated to participate in viral assembly and budding. Moreover, the functions of matrix protein identified in other paramyxoviruses still remain unknown in NDV. This review compares the functions of matrix protein between NDV and other paramyxoviruses, and focuses on the relationship of matrix protein to the virulence, replication and pathogenicity of NDV. Meanwhile, challenges and research prospects of NDV matrix protein are also discussed.
最近的研究发现，副粘病毒的基质蛋白是一种多功能病毒蛋白。除了抑制细胞基因的转录和翻译、调节病毒基因组的复制和转录以及招募细胞蛋白以促进病毒组装和出芽外，基质蛋白还可通过其泛素化和磷酸化增强副粘病毒的复制。然而，作为副粘病毒的一员，新城疫病毒（NDV）的基质蛋白仅被证明参与病毒组装和出芽。此外，在其他副粘病毒中鉴定出的基质蛋白功能在NDV中仍然未知。本文综述比较了NDV与其他副粘病毒之间基质蛋白的功能，并重点关注基质蛋白与NDV毒力、复制和致病性的关系。同时，还讨论了NDV基质蛋白面临的挑战和研究前景。
