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干细胞疗法在组织修复和再生中的现状。

Current Status of Stem Cell Therapies in Tissue Repair and Regeneration.

机构信息

NSHM College of Pharmaceutical Technology, NSHM Knowledge Campus, Kolkata Group of Institutions, 124 BL Saha Road, Kolkata-700053, West Bengal, India.

Rungta College of Pharmaceutical Sciences and Research, Bhilai, Chhattisgarh 490024, India.

出版信息

Curr Stem Cell Res Ther. 2019;14(2):117-126. doi: 10.2174/1574888X13666180502103831.

Abstract

Tissue engineering is a multi-disciplinary field such as material science, life science, and bioengineering that are necessary to make artificial tissue or rejuvenate damaged tissue. Numerous tissue repair techniques and substitute now exist even though it has several shortcomings; these shortcomings give a good reason for the continuous research for more acceptable tissue-engineered substitutes. The search for and use of a suitable stem cell in tissue engineering is a promising concept. Stem cells have a distinctive capability to differentiate and self-renew that make more suitable for cell-based therapies in tissue repair and regeneration. This review article focuses on stem cell for tissue engineering and their methods of manufacture with their application in nerve, bone, skin, cartilage, bladder, cardiac, liver tissue repair and regeneration.

摘要

组织工程是一门多学科领域,涉及材料科学、生命科学和生物工程等学科,旨在制造人工组织或修复受损组织。尽管存在一些缺点,但现在已经有许多组织修复技术和替代物,这些缺点为不断研究更可接受的组织工程替代物提供了很好的理由。在组织工程中寻找和使用合适的干细胞是一个很有前途的概念。干细胞具有独特的分化和自我更新能力,使其更适合用于细胞治疗来修复和再生组织。本文综述了干细胞在神经、骨骼、皮肤、软骨、膀胱、心脏、肝脏组织修复和再生中的应用及其制造方法。

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