CXCR4，在生理和疾病状态下调节中性粒细胞迁移的主调控因子。
CXCR4, the master regulator of neutrophil trafficking in homeostasis and disease.
机构信息
IRD Section, Respiratory Division, NHLI, Faculty of Medicine, Imperial College London, London, UK.
出版信息
Eur J Clin Invest. 2018 Nov;48 Suppl 2(Suppl Suppl 2):e12949. doi: 10.1111/eci.12949. Epub 2018 May 23.
BACKGROUND
Chemokines play a critical role in orchestrating the distribution and trafficking of neutrophils in homeostasis and disease.
RESULTS
The CXCR4/CXCL12 chemokine axis has been identified as a central regulator of these processes.
CONCLUSION
In this review, we focus on the role of CXCR4/CXCL12 chemokine axis in regulating neutrophil release from the bone marrow and the trafficking of senescent neutrophils back to the bone marrow for clearance under homeostasis and disease. We also discuss the role of CXCR4 in fine-tuning neutrophil responses in the context of inflammation.
背景
趋化因子在协调中性粒细胞在稳态和疾病中的分布和迁移中起着关键作用。
结果
CXCR4/CXCL12 趋化因子轴已被确定为这些过程的中央调节剂。
结论
在这篇综述中，我们专注于 CXCR4/CXCL12 趋化因子轴在调节中性粒细胞从骨髓中释放以及在稳态和疾病下衰老中性粒细胞回迁至骨髓进行清除中的作用。我们还讨论了 CXCR4 在炎症背景下精细调节中性粒细胞反应的作用。
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