Gezer N S, Gezer C, Ekin A, Yesilirmak D C, Solmaz U, Dogan A, Guleryuz H
Clin Exp Obstet Gynecol. 2016;43(4):490-494.
The purpose of this study is to establish the obstetric and early neurological outcomes of fetuses diagnosed with intrauterine ventriculomegaly (VM).
This retrospective study included 27 fetuses with VM diagnosed by ultrasound (US) and referred for in utero magnetic resonance imaging (MRI). US and MRI reports and laboratory test results were obtained including chromosome analysis, congenital infections, and first and second trimester screening tests. Infants were evaluated for clinical outcome for six to 24 months of age.
Twenty (51%) fetuses had mild and 19 (49%) fetuses had severe VM. Accompanying central nervous system (CNS) anomalies were statistically significantly more common in severe VM group. The outcome of mild VM group was statistically significantly better than in the severe VM group.
The authors conclude that ventricular dimension is a significant prognostic factor to detennine the outcome of fetal cerebral VM. The presence of accompanying CNS anomalies is more common with severe VM and may be considered as an unfavorable indicator for a better outcome.
本研究旨在确定诊断为宫内脑室扩大（VM）的胎儿的产科及早期神经学结局。
这项回顾性研究纳入了27例经超声（US）诊断为VM并转诊接受宫内磁共振成像（MRI）检查的胎儿。获取了US和MRI报告以及实验室检查结果，包括染色体分析、先天性感染以及孕早期和孕中期筛查试验。对6至24月龄婴儿的临床结局进行了评估。
20例（51%）胎儿为轻度VM，19例（49%）胎儿为重度VM。重度VM组中伴有中枢神经系统（CNS）异常的情况在统计学上更为常见。轻度VM组的结局在统计学上显著优于重度VM组。
作者得出结论，脑室大小是决定胎儿脑VM结局的一个重要预后因素。重度VM更常伴有CNS异常，这可能被视为预后不佳的一个指标。
