Slopień R, Rózycka A, Slopień A, Pawlak M, Warenik-Szymankiewicz A, Sajdak S, Jagodziński P
Clin Exp Obstet Gynecol. 2016;43(4):495-499.
The subject of the study is the evaluation of the correlation between the polymorphism of candidate genes in the etiology of depression and the occurrence of the symptoms of the climacteric syndrome in women during menopause. The group subjected to the study comprised of 203 women aged between 42-65 years: 71 of them still menstruated (premenopausal group) and 132 at least one year after the last period (postmenopausal group), admitted to the Department of Gynecological Endocrinology at the University of Medical Sciences in Poznan with symptoms of the climacteric syndrome All the examined women were evaluated according to the degree of severity of the climacteric syndrome symptoms using the Kupperman index and the concentration of FSH, LH hormones, 17β-estradiol, PRL, total testosterone, and DHEAS in peripheral blood serum. Among the candidate genes in the aetiology of depression the following were selected for the research: the serotonergic system receptor genes: 5HTR2A, 5HTR1B, 5HTR2C, TPH 1, TPH2, and MAO-A; the genes of noradrenergic and dopaminergic systems (COMT, NET), the genes of the GABAergic (GABRBl) system, a gene of the estrogen receptor (ESR1), and the genes of the enzymes crucial in the methyl cycle (MTHRF, MTR, and MTHFD1). With regards to the correlation between the examined polymorphisms and the occurrence of the symptoms of the climacteric syndrome, the associations analysis indicated a connection between GABRBl.TaqI polymorphism and the occurrence of vertigo in premenopausal women (0.0198; after correction: 0.0497 CC to CA). The correlation was also found regarding the examined polymorphisms and the concentration of the examined hormones in blood serum: TPH1.MaeI polymorphism and the LH concentration in the postmenopausal group (0.004; after correction: 0.014 CC to CA), NET.Eco1471 polymorphism, and the 17β-estradiol concentration in the postmenopausal group (0.0208; after correction: 0.048 GG to GA) and HTR2AMspI polymorphism and PRL concentration in all examined women (0.03; after correction: 0.038 TT to CT).
该研究的主题是评估抑郁症病因中候选基因的多态性与绝经期间女性更年期综合征症状发生之间的相关性。接受研究的组由203名年龄在42至65岁之间的女性组成：其中71名仍有月经（绝经前组），132名在最后一次月经后至少一年（绝经后组），她们因更年期综合征症状入住波兹南医科大学妇科内分泌科。所有接受检查的女性均使用库珀曼指数以及外周血血清中促卵泡生成素（FSH）、促黄体生成素（LH）、17β-雌二醇、催乳素（PRL）、总睾酮和硫酸脱氢表雄酮（DHEAS）的浓度，根据更年期综合征症状的严重程度进行评估。在抑郁症病因的候选基因中，选择了以下基因进行研究：血清素能系统受体基因：5HTR2A、5HTR1B、5HTR2C、TPH 1、TPH2和MAO - A；去甲肾上腺素能和多巴胺能系统的基因（COMT、NET）、γ-氨基丁酸能（GABRBl）系统的基因、雌激素受体（ESR1）的基因以及甲基循环中关键酶的基因（MTHRF、MTR和MTHFD1）。关于所检测的多态性与更年期综合征症状发生之间的相关性，关联分析表明GABRBl.TaqI多态性与绝经前女性眩晕的发生之间存在联系（0.0198；校正后：0.0497，CC对CA）。在所检测的多态性与血清中所检测激素的浓度之间也发现了相关性：TPH1.MaeI多态性与绝经后组中LH的浓度（0.004；校正后：0.014，CC对CA）、NET.Eco1471多态性与绝经后组中17β-雌二醇的浓度（0.0208；校正后：0.048，GG对GA）以及HTR2AMspI多态性与所有接受检查女性中PRL的浓度（0.03；校正后：0.038，TT对CT）。
