Department of Surgery, University of Illinois at Chicago, 840 South Wood Street, Suite 402, Chicago, IL 60612, USA.
Department of Surgery, University of Illinois at Chicago, 840 South Wood Street, Suite 402, Chicago, IL 60612, USA.
Gastroenterol Clin North Am. 2018 Jun;47(2):369-380. doi: 10.1016/j.gtc.2018.01.008. Epub 2018 Apr 4.
Living donor intestinal transplantation (LDIT) has been improved leading to results comparable to those obtained with deceased donors. LDIT should be limited to specific indications and patient selection. The best indication is combined living donor intestinal/liver transplantation in pediatric recipients with intestinal and hepatic failure; the virtual elimination of waiting time may avoid the high mortality experienced by candidates on the deceased waiting list. Potentially, LDIT could be used in highly sensitized recipients to allow the application of de-sensitization protocols. In the case of available identical twins or HLA-identical sibling, LDIT has a significant immunologic advantage and should be offered.
活体供肠移植(LDIT)得到了改进,其结果可与已故供者移植相媲美。LDIT 应限于特定的适应证和患者选择。最佳适应证是儿童患者的肠-肝联合活体供者移植,这些患者同时存在肠和肝衰竭;这种方法可使等待时间接近为零,从而避免等待已故供者的患者所经历的高死亡率。LDIT 可能适用于高致敏受者,从而使脱敏方案得以应用。在有可利用的同卵双胞胎或 HLA 完全匹配的同胞的情况下,LDIT 具有显著的免疫优势,应予以提供。