Department of Nephrology, SUNY Downstate Medical Center, 450 Clarkson Avenue, MSC 40, Brooklyn, NY 11203, USA.
Department of Surgery, SUNY Downstate Medical Center, 450 Clarkson Avenue, MSC 40, Brooklyn, NY 11203, USA.
Gastroenterol Clin North Am. 2018 Jun;47(2):417-441. doi: 10.1016/j.gtc.2018.01.009.
Successful pancreas transplantation is still the only method to restore short-term and long-term insulin independence and good metabolic control for patients with diabetes. Since the first transplant in 1966, tremendous progress in outcome was made; however, transplant numbers have declined since 2004. This article describes the development and risk factors of pancreas transplantation with or without a kidney graft between 2001 and 2016. Patient survival and graft function improved significantly owing to careful recipient and donor selection, which reduced technical failure and immunologic graft loss rates.
成功的胰腺移植仍然是恢复糖尿病患者短期和长期胰岛素独立性和良好代谢控制的唯一方法。自 1966 年首例移植以来，其结果取得了巨大进展；然而，自 2004 年以来，移植数量有所下降。本文描述了 2001 年至 2016 年间胰腺移植伴或不伴肾移植的发展和风险因素。由于仔细的受者和供者选择，降低了技术失败和免疫性移植物丧失率，患者生存率和移植物功能显著改善。
