Postgraduate Program in Dentistry, Federal University of Santa Catarina, Florianópolis, Brazil.
Brazilian Centre for Evidence-based Research, Florianópolis, Brazil.
J Oral Pathol Med. 2018 Aug;47(7):633-640. doi: 10.1111/jop.12726. Epub 2018 Jun 6.
Oral potentially malignant disorders (OPMD) are chronic conditions, which have a higher risk of transformation to oral squamous cell carcinoma. The aim of this systematic review and meta-analysis was to answer the question: "What is the prevalence of oral potentially malignant disorders among adults?" Studies reporting the prevalence of these conditions (leukoplakia, erythroplakia, oral submucous fibrosis [OSMF], and actinic cheilitis) were selected, only studies in which a clinical assessment and histopathological confirmation were performed were included. Of the 5513 studies, 22 met the inclusion criteria for qualitative and quantitative analyses. The risk of bias (RoB) of the selected studies was assessed using the Joanna Briggs Institute Critical Appraisal Checklist for Studies Reporting Prevalence Data. Seven studies were classified as high risk, 12 as moderate risk, and 3 as low RoB. The meta-analysis showed that the prevalence of OPMD was 4.47% (95% CI = 2.43-7.08). The most prevalent OPMDs were OSMF (4.96%; 95% CI = 2.28-8.62) and leukoplakia (4.11%; 95% CI = 1.98-6.97). OPMDs were identified more commonly in males (59.99%; 95% CI = 41.27-77.30). Asian and South American/Caribbean populations had the highest prevalence rates of 10.54% (95% CI = 4.60-18.55) and 3.93% (95% CI = 2.43-5.77), respectively. The overall prevalence of OPMD worldwide was 4.47%, and males were more frequently affected by these disorders. The prevalence of OPMD differs between populations; therefore, further population-based studies may contribute to the better understanding of these differences.
口腔潜在恶性疾病（OPMD）是一种慢性疾病，其向口腔鳞状细胞癌转化的风险较高。本系统评价和荟萃分析的目的是回答以下问题：“成年人中口腔潜在恶性疾病的患病率是多少？” 选择报告这些疾病（白斑病、红斑病、口腔黏膜下纤维化 [OSMF] 和光化性唇炎）患病率的研究，仅纳入进行临床评估和组织病理学确认的研究。在 5513 项研究中，有 22 项符合定性和定量分析的纳入标准。使用 Joanna Briggs 研究所报告患病率数据的批判性评估清单评估选定研究的偏倚风险（RoB）。有 7 项研究被归类为高风险，12 项为中风险，3 项为低 RoB。荟萃分析显示，OPMD 的患病率为 4.47%（95%CI=2.43-7.08）。最常见的 OPMD 是 OSMF（4.96%；95%CI=2.28-8.62）和白斑病（4.11%；95%CI=1.98-6.97）。OPMD 在男性中更为常见（59.99%；95%CI=41.27-77.30）。亚洲和南美洲/加勒比地区的人群患病率最高，分别为 10.54%（95%CI=4.60-18.55）和 3.93%（95%CI=2.43-5.77）。OPMD 在全球的总体患病率为 4.47%，男性更容易受到这些疾病的影响。OPMD 的患病率在不同人群中存在差异；因此，进一步的基于人群的研究可能有助于更好地了解这些差异。
