[非嵌合型克兰费尔特综合征患者的显微外科睾丸取精术：143例报告]

[Microdissection testicular sperm extraction for patients with nonmosaic Klinefelter syndrome: A report of 143 cases].

作者信息

Mao Jia-Ming, Zhao Lian-Ming, Hong Kai, Tang Wen-Hao, Liu De-Feng, Lin Hao-Cheng, Wu Han, Zhang Hai-Tao, Zhang Hong-Liang, Yang Yu-Zhuo, Wang Ya-Peng, Lian Ying, Jiang Hui, Ma Lu-Lin, Qiao Jie

机构信息

Center of Reproductive Medicine, Peking University Third Hospital, Beijing 100191, China.

Department of Urology, Peking University Third Hospital, Beijing 100191, China.

出版信息

Zhonghua Nan Ke Xue. 2017 Dec;23(12):1075-1079.

PMID:29738176

Abstract

OBJECTIVE

To investigate the clinical application and outcomes of microdissection testicular sperm extraction (micro-TESE) in patients with nonmosaic Klinefelter syndrome (KS).

METHODS

A total of 143 nonmosaic KS patients underwent micro-TESE in the Center of Reproductive Medicine of Peking University Third Hospital between July 2012 and August 2016. We analyzed their clinical and follow-up data and evaluated the outcomes.

RESULTS

Spermatozoa were successfully retrieved from the testicular tissue in 44.76% (64/143) of the patients, 84.4% (54/64) by unilateral and 15.6% (10/64) by bilateral micro-TESE. Seventy-five of the KS patients were followed up in the years of 2014 and 2015. Of the 34 patients with successful sperm retrieval, 73.52% (25/34) achieved clinical pregnancy and 8 boys and 8 girls were already born in 14 of the 25 cases.

CONCLUSIONS

The micro-TESE is a useful method for sperm retrieval in nonmosaic KS patients, with high rates of sperm retrieval, clinical pregnancy, and birth of biological offspring.

摘要

目的

探讨显微切割睾丸取精术（micro-TESE）在非嵌合型克兰费尔特综合征（KS）患者中的临床应用及效果。

方法

2012年7月至2016年8月，共有143例非嵌合型KS患者在北京大学第三医院生殖医学中心接受了micro-TESE。我们分析了他们的临床和随访数据，并评估了治疗效果。

结果

44.76%（64/143）的患者从睾丸组织中成功获取精子，其中单侧micro-TESE获取精子的成功率为84.4%（54/64），双侧micro-TESE为15.6%（10/64）。2014年和2015年对其中75例KS患者进行了随访。在34例成功获取精子的患者中，73.52%（25/34）实现了临床妊娠，25例中有14例已产下8名男婴和8名女婴。