Kinnunen Lotta, Niemelä Mika, Hakko Helinä, Miettunen Jouko, Merikukka Marko, Karttunen Vesa, Ristikari Tiina, Gissler Mika, Räsänen Sami
a Center for Life Course Health Research , University of Oulu , Oulu , Finland.
b Medical Research Center Oulu , Oulu University Hospital and University of Oulu , Oulu , Finland.
Brain Inj. 2018;32(7):933-940. doi: 10.1080/02699052.2018.1470331. Epub 2018 May 8.
To investigate whether parental TBI increases the overall risk for psychiatric disorders and the risk for specific psychiatric diagnoses in the children affected by parental TBI.
The 1987 Finnish Birth Cohort (n = 59 476) were followed up through national registers from birth to the end of 2008. The diagnoses of cohort members and their parents were obtained from the Care Register of Health Care, provided by the National Institute of Health and Welfare.
During the 21-year follow-up, the likelihood for psychiatric diagnoses being assessed in psychiatric care was significantly increased in males with any mental disorder (odds ratio (OR) = 1.43), substance-use-related disorders (OR = 1.71) and behavioural and emotional disorders (OR = 1.75), and in females with disorders of psychological development (OR = 1.85).
Children affected by parental TBI are at increased risk for psychiatric disorders: males for externalizing disorders and females for developmental disorders. Observed gender interactions in the association between parental TBI and the psychiatric disorders of children warrant further study.
探讨父母创伤性脑损伤(TBI)是否会增加受其影响儿童患精神疾病的总体风险以及特定精神疾病诊断的风险。
对1987年芬兰出生队列(n = 59476)从出生到2008年底通过国家登记册进行随访。队列成员及其父母的诊断信息来自国家卫生与福利研究所提供的医疗保健护理登记册。
在21年的随访期间,患有任何精神障碍的男性(优势比(OR)= 1.43)、物质使用相关障碍(OR = 1.71)以及行为和情绪障碍(OR = 1.75),和患有心理发育障碍的女性(OR = 1.85)在精神科护理中接受精神疾病诊断的可能性显著增加。
受父母TBI影响的儿童患精神疾病的风险增加:男性患外化性障碍,女性患发育性障碍。父母TBI与儿童精神疾病之间关联中观察到的性别交互作用值得进一步研究。