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Deposition of phosphorylated amyloid-β in brains of aged nonhuman primates and canines.

作者信息

Kumar Sathish, Frost Jeffrey L, Cotman Carl W, Head Elizabeth, Palmour Roberta, Lemere Cynthia A, Walter Jochen

机构信息

Department of Neurology, University of Bonn, 53127 Bonn, Germany.

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.

出版信息

Brain Pathol. 2018 May;28(3):427-430. doi: 10.1111/bpa.12573.

DOI:10.1111/bpa.12573
PMID:29740941
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8028592/
Abstract
摘要

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2
Phosphorylation of the amyloid β-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity.淀粉样β肽在丝氨酸26处的磷酸化可稳定寡聚体组装并增加神经毒性。
Acta Neuropathol. 2016 Apr;131(4):525-37. doi: 10.1007/s00401-016-1546-0. Epub 2016 Feb 22.
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Cerebrovascular disease in ageing and Alzheimer's disease.衰老与阿尔茨海默病中的脑血管疾病
Acta Neuropathol. 2016 May;131(5):645-58. doi: 10.1007/s00401-015-1522-0. Epub 2015 Dec 28.
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Accelerating Alzheimer's research through 'natural' animal models.通过“天然”动物模型加速阿尔茨海默病研究。
Curr Opin Psychiatry. 2015 Mar;28(2):155-64. doi: 10.1097/YCO.0000000000000137.
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Investigation of Aβ phosphorylated at serine 8 (pAβ) in Alzheimer's disease, dementia with Lewy bodies and vascular dementia.阿尔茨海默病、路易体痴呆和血管性痴呆中丝氨酸8磷酸化Aβ（pAβ）的研究。
Neuropathol Appl Neurobiol. 2015 Jun;41(4):428-44. doi: 10.1111/nan.12212.
6
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Brain. 2014 Mar;137(Pt 3):887-903. doi: 10.1093/brain/awt362. Epub 2014 Feb 10.
7
Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models.人类、非人类灵长类动物、犬类以及阿尔茨海默病样转基因小鼠模型大脑中的焦谷氨酸盐-3 淀粉样蛋白沉积。
Am J Pathol. 2013 Aug;183(2):369-81. doi: 10.1016/j.ajpath.2013.05.005. Epub 2013 Jun 7.
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A canine model of human aging and Alzheimer's disease.一种人类衰老和阿尔茨海默病的犬类模型。
Biochim Biophys Acta. 2013 Sep;1832(9):1384-9. doi: 10.1016/j.bbadis.2013.03.016. Epub 2013 Mar 23.
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