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体外受精周期中孕激素过早升高的不良影响：文献综述。

Adverse effect of prematurely elevated progesterone in in vitro fertilization cycles: a literature review.

机构信息

Program in Reproductive Endocrinology and Gynecology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health. Bethesda, MD, USA.

出版信息

Biol Reprod. 2018 Jul 1;99(1):45-51. doi: 10.1093/biolre/ioy082.

DOI:10.1093/biolre/ioy082
PMID:29741591
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6279063/
Abstract

Premature progesterone (P) elevation was commonly seen in IVF prior to the utilization of GnRH analogues for suppression of endogenous gonadotropin release. The cause and effect of premature P elevation has finally been better elucidated in the past decade. Although still occurring in 5-38% of all IVF cycles, the adverse effects of premature P elevation on pregnancy outcomes are now well known.

摘要

在使用 GnRH 类似物抑制内源性促性腺激素释放之前，体外受精（IVF）中常出现孕激素过早升高。在过去的十年中，孕激素过早升高的原因和后果终于得到了更好的阐明。尽管在所有 IVF 周期中仍有 5-38%发生，但孕激素过早升高对妊娠结局的不良影响现在已广为人知。

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本文引用的文献

1
FSH Stimulation promotes progesterone synthesis and output from human granulosa cells without luteinization.FSH 刺激可促进人颗粒细胞孕激素的合成和分泌，而不会导致黄体化。
Hum Reprod. 2017 Mar 1;32(3):643-652. doi: 10.1093/humrep/dex010.
2
Revisiting the progesterone to oocyte ratio.重新审视孕酮与卵母细胞的比例。
Fertil Steril. 2017 Mar;107(3):671-676.e2. doi: 10.1016/j.fertnstert.2016.11.019. Epub 2017 Jan 6.
3
The slow growing embryo and premature progesterone elevation: compounding factors for embryo-endometrial asynchrony.胚胎生长缓慢与孕酮过早升高：胚胎与子宫内膜不同步的复合因素。
Hum Reprod. 2017 Feb;32(2):362-367. doi: 10.1093/humrep/dew296. Epub 2016 Dec 16.
4
Does elevated progesterone on day of oocyte maturation play a role in the racial disparities in IVF outcomes?卵母细胞成熟当天孕酮水平升高是否在体外受精结果的种族差异中起作用？
Reprod Biomed Online. 2017 Feb;34(2):154-161. doi: 10.1016/j.rbmo.2016.11.002. Epub 2016 Nov 16.
5
Elevated progesterone on the trigger day does not impair the outcome of Human Menotrophins Gonadotrophin and Medroxyprogesterone acetate treatment cycles.扳机日时孕酮水平升高并不影响人绝经期促性腺激素、醋酸甲羟孕酮治疗周期的结局。
Sci Rep. 2016 Aug 8;6:31112. doi: 10.1038/srep31112.
6
What is the contribution of embryo-endometrial asynchrony to implantation failure?胚胎-子宫内膜不同步对着床失败有何影响？
J Assist Reprod Genet. 2016 Nov;33(11):1419-1430. doi: 10.1007/s10815-016-0773-6. Epub 2016 Aug 1.
7
Is the effect of premature elevated progesterone augmented by human chorionic gonadotropin versus gonadotropin-releasing hormone agonist trigger?与促性腺激素释放激素激动剂触发相比，人绒毛膜促性腺激素是否会增强过早升高的孕酮的作用？
Fertil Steril. 2016 Sep 1;106(3):584-589.e1. doi: 10.1016/j.fertnstert.2016.04.024. Epub 2016 May 10.
8
A high response to controlled ovarian stimulation induces premature luteinization with a negative impact on pregnancy outcomes in a gonadotropin-releasing hormone antagonist cycle.在促性腺激素释放激素拮抗剂周期中，对控制性卵巢刺激的高反应会诱导过早黄素化，对妊娠结局产生负面影响。
Clin Exp Reprod Med. 2015 Dec;42(4):149-55. doi: 10.5653/cerm.2015.42.4.149. Epub 2015 Dec 31.
9
Does a frozen embryo transfer ameliorate the effect of elevated progesterone seen in fresh transfer cycles?冻融胚胎移植是否能改善新鲜胚胎移植周期中孕酮升高的影响？
Fertil Steril. 2016 Jan;105(1):93-9.e1. doi: 10.1016/j.fertnstert.2015.09.015. Epub 2015 Oct 9.
10
Ratio of progesterone-to-number of follicles as a prognostic tool for in vitro fertilization cycles.孕酮与卵泡数量的比值作为体外受精周期的一种预后工具。
J Assist Reprod Genet. 2015 Jun;32(6):951-7. doi: 10.1007/s10815-015-0487-1. Epub 2015 May 1.