围产期 HIV 感染孕妇母婴 HIV 传播的风险是否更高？
Is There a Higher Risk of Mother-to-child Transmission of HIV Among Pregnant Women With Perinatal HIV Infection?
机构信息
From the University of Texas Health Science Center at Houston, Houston, Texas.
Department of Epidemiology, Center for Biostatistics in AIDS Research (CBAR), Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
出版信息
Pediatr Infect Dis J. 2018 Dec;37(12):1267-1270. doi: 10.1097/INF.0000000000002084.
Abstract
Cases of mother-to-child-transmission in the Surveillance Monitoring of ART Toxicities Study of Pediatric HIV/AIDS Cohort Study were identified from 2007 to 2015. Among 2123 births, 9 infants were HIV infected, giving a mother-to-child-transmission rate of 0.5% (95% confidence interval: 0.3%-1.0%). Mothers with perinatal HIV infections had a higher mother-to-child-transmission rate (1.1%; 95% confidence interval: 0.3%-4.3%) than mothers without perinatal HIV infections (0.4%; 95% confidence interval: 0.2%-1.0%), associated with a greater likelihood of detectable viral load at delivery.
摘要
从 2007 年到 2015 年，在儿科 HIV/AIDS 队列研究的 ART 毒性监测研究中发现了母婴传播病例。在 2123 例分娩中，有 9 例婴儿感染了 HIV，母婴传播率为 0.5%（95%置信区间：0.3%-1.0%）。围产期 HIV 感染的母亲母婴传播率更高（1.1%；95%置信区间：0.3%-4.3%），而非围产期 HIV 感染的母亲母婴传播率更低（0.4%；95%置信区间：0.2%-1.0%），与分娩时可检测到的病毒载量更相关。
相似文献
1
Is There a Higher Risk of Mother-to-child Transmission of HIV Among Pregnant Women With Perinatal HIV Infection?围产期 HIV 感染孕妇母婴 HIV 传播的风险是否更高？
Pediatr Infect Dis J. 2018 Dec;37(12):1267-1270. doi: 10.1097/INF.0000000000002084.
2
Estimated Perinatal HIV Infection Among Infants Born in the United States, 2002-2013.2002 - 2013年美国出生婴儿的围产期HIV感染估计情况
JAMA Pediatr. 2017 May 1;171(5):435-442. doi: 10.1001/jamapediatrics.2016.5053.
3
The effect of maternal viral load on the risk of perinatal transmission of HIV-1. New York City Perinatal HIV Transmission Collaborative Study Group.孕产妇病毒载量对HIV-1围产期传播风险的影响。纽约市围产期HIV传播协作研究组。
AIDS. 1997 Mar 15;11(4):437-44. doi: 10.1097/00002030-199704000-00006.
4
Missed Opportunities for Prevention of Mother-to-Child Transmission of Human Immunodeficiency Virus.预防人类免疫缺陷病毒母婴传播的错失机会
Obstet Gynecol. 2017 Apr;129(4):621-628. doi: 10.1097/AOG.0000000000001929.
5
Maternal viral load and timing of mother-to-child HIV transmission, Bangkok, Thailand. Bangkok Collaborative Perinatal HIV Transmission Study Group.泰国曼谷母婴HIV传播中的母亲病毒载量及传播时间。曼谷围产期HIV传播协作研究组。
AIDS. 1999 Feb 25;13(3):407-14. doi: 10.1097/00002030-199902250-00014.
6
Anti-retroviral therapy failure in HIV-1 infected pregnant women and its associated risk of HIV transmission.抗逆转录病毒疗法治疗失败与 HIV-1 感染孕妇母婴传播的风险。
Arch Gynecol Obstet. 2020 Nov;302(5):1229-1235. doi: 10.1007/s00404-020-05743-8. Epub 2020 Aug 14.
7
Adolescent and young pregnant women at increased risk of mother-to-child transmission of HIV and poorer maternal and infant health outcomes: A cohort study at public facilities in the Nelson Mandela Bay Metropolitan district, Eastern Cape, South Africa.青少年及年轻孕妇母婴传播艾滋病毒风险增加，母婴健康结局较差：南非东开普省纳尔逊·曼德拉湾都会区公共设施的队列研究
S Afr Med J. 2014 Dec;104(12):874-80. doi: 10.7196/samj.8207.
8
9
Clinical malaria diagnosis in pregnancy in relation to early perinatal mother-to-child transmission of HIV: a prospective cohort study.妊娠期间疟疾的临床诊断与HIV早期母婴传播的关系：一项前瞻性队列研究。
HIV Med. 2014 May;15(5):276-85. doi: 10.1111/hiv.12111. Epub 2013 Nov 11.
10
Low rates of mother-to-child transmission of HIV following effective pregnancy interventions in the United Kingdom and Ireland, 2000-2006.2000 - 2006年英国和爱尔兰有效孕期干预措施实施后，母婴传播艾滋病毒的低发生率
AIDS. 2008 May 11;22(8):973-81. doi: 10.1097/QAD.0b013e3282f9b67a.
引用本文的文献
1
Mother-to-Child Transmission of Human Immunodeficiency Virus and Its Determinants: Lessons Learnt from the Test and Treat Strategy at a Regional Hospital in Cameroon.人类免疫缺陷病毒的母婴传播及其决定因素：喀麦隆一家地区医院从检测与治疗策略中吸取的经验教训。
Turk Arch Pediatr. 2025 May 2;60(3):301-306. doi: 10.5152/TurkArchPediatr.2025.24144.
2
Second-generation mother-to-child HIV transmission in South Africa is characterized by poor outcomes.南非的第二代母婴 HIV 传播特点是结局较差。
AIDS. 2021 Aug 1;35(10):1597-1604. doi: 10.1097/QAD.0000000000002915.
3
The next generation: Pregnancy in adolescents and women living with perinatally acquired HIV in South Africa.下一代：南非青春期少女和围产期感染艾滋病毒的女性的妊娠问题。
S Afr Med J. 2021 Mar 2;111(3):260-264. doi: 10.7196/SAMJ.2021.v111i3.14987.
4
Repeat Pregnancies Among US Women Living With HIV in the SMARTT Study: Temporal Changes in HIV Disease Status and Predictors of Preterm Birth.SMARTT 研究中 HIV 感染者重复妊娠：HIV 疾病状况的时间变化及早产预测因素
J Acquir Immune Defic Syndr. 2020 Nov 1;85(3):346-354. doi: 10.1097/QAI.0000000000002445.
5
Trends in post-partum viral load among women living with perinatal HIV infection in the USA: a prospective cohort study.美国围生期 HIV 感染女性产后病毒载量趋势：一项前瞻性队列研究。
Lancet HIV. 2020 Mar;7(3):e184-e192. doi: 10.1016/S2352-3018(19)30339-X. Epub 2019 Dec 20.
本文引用的文献
1
UK Mother-to-Child HIV Transmission Rates Continue to Decline: 2012-2014.英国母婴HIV传播率持续下降：2012 - 2014年。
Clin Infect Dis. 2017 Feb 15;64(4):527-528. doi: 10.1093/cid/ciw791.
2
Antiretroviral Drug Resistance Among Children and Youth in the United States With Perinatal HIV.美国围产期感染艾滋病毒的儿童和青少年中的抗逆转录病毒药物耐药性
Clin Infect Dis. 2016 Jul 1;63(1):133-137. doi: 10.1093/cid/ciw213. Epub 2016 Apr 7.
3
Missed opportunities for prevention of mother-to-child transmission in the United States.美国预防母婴传播的错失机会。
AIDS. 2015 Jul 31;29(12):1511-5. doi: 10.1097/QAD.0000000000000710.
4
Why are Children Still Being Infected with HIV? Impact of an Integrated Public Health and Clinical Practice Intervention on Mother-to-Child HIV Transmission in Las Vegas, Nevada, 2007-2012.为什么儿童仍会感染艾滋病毒？2007年至2012年在内华达州拉斯维加斯开展的公共卫生与临床实践综合干预对母婴艾滋病毒传播的影响
Ann Med Health Sci Res. 2015 Jul-Aug;5(4):253-9. doi: 10.4103/2141-9248.160189.
5
Impact of HIV-1 infection and pregnancy on maternal health: comparison between perinatally and behaviorally infected young women.人类免疫缺陷病毒1型（HIV-1）感染与妊娠对孕产妇健康的影响：围产期感染与行为感染年轻女性的比较
Adolesc Health Med Ther. 2013 Feb 21;4:51-8. doi: 10.2147/AHMT.S39885. eCollection 2013.
6
Earlier initiation of ART and further decline in mother-to-child HIV transmission rates, 2000-2011.2000 - 2011年，抗逆转录病毒治疗的更早启动以及母婴传播艾滋病毒率的进一步下降。
AIDS. 2014 Apr 24;28(7):1049-57. doi: 10.1097/QAD.0000000000000212.
7
A framework for elimination of perinatal transmission of HIV in the United States.在美国消除艾滋病毒母婴传播的框架。
Pediatrics. 2012 Oct;130(4):738-44. doi: 10.1542/peds.2012-0194. Epub 2012 Sep 3.
8
Correlates of mother-to-child transmission of HIV in the United States and Puerto Rico.美国和波多黎各的母婴 HIV 传播相关因素。
Pediatrics. 2012 Jan;129(1):e74-81. doi: 10.1542/peds.2010-3691. Epub 2011 Dec 5.
9
In utero and postnatal exposure to antiretrovirals among HIV-exposed but uninfected children in the United States.在美国，HIV 暴露但未感染儿童的宫内和产后暴露于抗逆转录病毒药物的情况。
AIDS Patient Care STDS. 2011 Jul;25(7):385-94. doi: 10.1089/apc.2011.0068. Epub 2011 Jun 10.
10
Prevalence and incidence of vertically acquired HIV infection in the United States.美国垂直传播的艾滋病毒感染的患病率和发病率。
JAMA. 1995 Sep 27;274(12):952-5.
Zotero 插件