Graff-Lonnevig V, Hedlin G, Lindfors A
Paediatric Department, Sachs' Children's Hospital, Stockholm, Sweden.
Arch Dis Child. 1988 Nov;63(11):1342-6. doi: 10.1136/adc.63.11.1342.
A total of 298 children with a history of adverse reactions in connection with oral penicillin treatment were investigated with a radioallergosorbent test for penicillin metabolites, the skin prick test, and oral challenge with penicillin V. No severe reactions were seen. In 30 (10%) of the subjects slight to moderate skin reactions were observed on the seventh to 10th day of the challenge period. Between one to four years after the oral challenge 222 children were reinvestigated by interview. One hundred and ten had been given treatment by penicillin and 103 (94%) of these children tolerated the new treatment well and without any adverse reactions. We conclude that the term 'penicillin allergy' is often misused. Such a diagnosis should be established by clinical investigation.
对总共298名有口服青霉素治疗相关不良反应史的儿童进行了青霉素代谢产物的放射变应原吸附试验、皮肤点刺试验和青霉素V口服激发试验。未观察到严重反应。在30名（10%）受试者中，在激发期的第7至10天观察到轻微至中度的皮肤反应。口服激发试验后1至4年，通过访谈对222名儿童进行了再次调查。其中110名儿童接受了青霉素治疗，这些儿童中有103名（94%）对新的治疗耐受良好且无任何不良反应。我们得出结论，“青霉素过敏”这一术语经常被滥用。这种诊断应该通过临床调查来确立。
