Center of Excellence for Stem Cells and Regenerative Medicine, Zewail City of Science and Technology, 6th of October, Giza, Egypt.
Faculty of Medicine, Menoufia University, Shebin El Kom, Menoufia, Egypt.
Oxid Med Cell Longev. 2018 Mar 18;2018:3250864. doi: 10.1155/2018/3250864. eCollection 2018.
Based on animal studies, adult mesenchymal stromal cells (MSCs) are promising for the treatment of pancreatitis. However, the best type of this form of cell therapy and its mechanism of action remain unclear.
We searched the PubMed, Web of Science, Scopus, Google Scholar, and Clinical Trials.gov websites for studies using MSCs as a therapy for both acute and chronic pancreatitis published until September 2017.
We identified 276 publications; of these publications, 18 met our inclusion criteria. In animal studies, stem cell therapy was applied more frequently for acute pancreatitis than for chronic pancreatitis. No clinical trials were identified. MSC therapy ameliorated pancreatic inflammation in acute pancreatitis and pancreatic fibrosis in chronic pancreatitis. Bone marrow and umbilical cord MSCs were the most frequently administered cell types. Due to the substantial heterogeneity among the studies regarding the type, source, and dose of MSCs used, conducting a meta-analysis was not feasible to determine the best type of MSCs.
The available data were insufficient for determining the best type of MSCs for the treatment of acute or chronic pancreatitis; therefore, clinical trials investigating the use of MSCs as therapy for pancreatitis are not warranted.
基于动物研究，间充质基质细胞（MSCs）在胰腺炎的治疗中具有广阔的应用前景。然而，这种细胞疗法的最佳类型及其作用机制尚不清楚。
我们检索了 PubMed、Web of Science、Scopus、Google Scholar 和 ClinicalTrials.gov 网站，查找截至 2017 年 9 月发表的关于 MSCs 治疗急性和慢性胰腺炎的研究。
我们共检索到 276 篇文献，其中 18 篇符合纳入标准。在动物研究中，干细胞疗法在急性胰腺炎中的应用比慢性胰腺炎更为广泛。未发现临床试验。MSC 疗法可改善急性胰腺炎的胰腺炎症和慢性胰腺炎的胰腺纤维化。骨髓和脐带 MSC 是最常使用的细胞类型。由于研究中关于 MSCs 的类型、来源和剂量存在较大的异质性，因此无法进行荟萃分析来确定最佳的 MSCs 类型。
目前的数据不足以确定治疗急性或慢性胰腺炎的最佳 MSCs 类型；因此，没有理由开展临床试验来研究 MSCs 作为胰腺炎治疗方法的应用。
