Hochstenbach Ron, Elferink Martin G, van Zon Patrick H A, Lichtenbelt Klaske D, van Harssel Jeske, Schuring-Blom Heleen, Page-Christiaens Godelieve C M L
Department of Genetics University Medical Centre Utrecht Utrecht The Netherlands.
Department of Obstetrics and Gynecology University Medical Centre Utrecht Utrecht The Netherlands.
Clin Case Rep. 2018 Mar 7;6(5):788-791. doi: 10.1002/ccr3.1424. eCollection 2018 May.
One of the confounders in noninvasive prenatal testing (NIPT) is the vanishing twin phenomenon. Prolonged contribution to the maternal Cell-free DNA (cfDNA) pool by cytotrophoblasts representing a demised, aneuploid cotwin may lead to a false-positive outcome for a normal, viable twin. We show that a vanishing trisomy-14 twin contributes to cfDNA for more than 2 weeks after demise.
无创产前检测（NIPT）中的一个混杂因素是消失双胎现象。代表已死亡、非整倍体双胎的细胞滋养层细胞对母体游离DNA（cfDNA）池的长期贡献可能导致正常、存活双胎出现假阳性结果。我们发现，消失的14三体双胎在死亡后2周多的时间里仍对cfDNA有贡献。
