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在自体干细胞移植前延长使用维布妥昔单抗将使难治性系统性间变性大细胞淋巴瘤获益。

Extended use of brentuximab vedotin before autologous stem-cell transplantation would benefit refractory systemic anaplastic large-cell lymphoma.

作者信息

Koh Youngil

机构信息

Department of Internal Medicine Seoul National University Hospital Seoul 03080 Korea.

出版信息

Clin Case Rep. 2018 Mar 8;6(5):798-801. doi: 10.1002/ccr3.1461. eCollection 2018 May.

DOI:10.1002/ccr3.1461
PMID:29744059
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5930222/
Abstract

The optimal number of brentuximab vedotin cycles in the treatment of systemic anaplastic large-cell lymphoma (sALCL) prior to autologous stem-cell transplantation (ASCT) is unknown. This case illustrates the possible benefit of prolonged brentuximab vedotin before ASCT in sALCL and may help clinical decision-making, especially in chemorefractory disease.

摘要

在自体干细胞移植(ASCT)之前,用于治疗系统性间变性大细胞淋巴瘤(sALCL)的最佳brentuximab vedotin疗程数尚不清楚。本病例说明了在sALCL患者进行ASCT之前延长使用brentuximab vedotin的潜在益处,并可能有助于临床决策,尤其是在化疗难治性疾病中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a09d/5930222/ea888686428c/CCR3-6-798-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a09d/5930222/1e03adb02507/CCR3-6-798-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a09d/5930222/ea888686428c/CCR3-6-798-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a09d/5930222/1e03adb02507/CCR3-6-798-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a09d/5930222/ea888686428c/CCR3-6-798-g002.jpg

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本文引用的文献

1
Brentuximab vedotin (SGN-35) in patients with relapsed or refractory systemic anaplastic large-cell lymphoma: results of a phase II study.本妥昔单抗维迪昔(SGN-35)治疗复发或难治性系统性间变大细胞淋巴瘤患者的Ⅱ期研究结果。
J Clin Oncol. 2012 Jun 20;30(18):2190-6. doi: 10.1200/JCO.2011.38.0402. Epub 2012 May 21.
2
Lysosomal trafficking and cysteine protease metabolism confer target-specific cytotoxicity by peptide-linked anti-CD30-auristatin conjugates.溶酶体运输和半胱氨酸蛋白酶代谢通过肽连接的抗CD30-澳瑞他汀缀合物赋予靶标特异性细胞毒性。
J Biol Chem. 2006 Apr 14;281(15):10540-7. doi: 10.1074/jbc.M510026200. Epub 2006 Feb 16.