Radiation Oncology, Università Campus Bio-Medico, Rome, Italy.
PLoS One. 2018 May 10;13(5):e0195506. doi: 10.1371/journal.pone.0195506. eCollection 2018.
Voluntary deep inspiration breath hold technique (vDIBH) is considered as the key to achieving the widest cardiac sparing in whole breast irradiation. Several techniques have been implemented to achieve a reproducible, fast and friendly treatment. The aim of the present study is to implement vDIBH using the ExacTrac (BrainLAB AG, Germany) monitoring system.
Women with left-sided breast cancer, younger than 50 years or with cardiac disease, underwent whole breast RT with vDIBH using the ExacTrac (BrainLAB AG, Germany) monitoring system. Simulations were performed with patients positioned supine on a breast board with both arms raised above the head. Five optical markers were placed on the skin around the border of the left breast gland and their position was referenced with ink marking. Each patient received a training session to find the individual deep inspiration level. Finally, a vDIBH CT was taken. All patients were also studied in free breathing (FB) in order to compare the dose distribution for PTV, heart and left anterior descending coronary artery (LAD). Pre-treatment verification was carried out through the ExacTrac (BrainLAB AG, Germany) system and verified with electronic portal imaging (EPI). Moreover, daily real time EPIs in during modality (captured during the beam delivery) were taken in order to check the reproducibility.
34 patients have been evaluated and 30 were eligible for vDIBH. Most patients showed small setup errors during the treatment course of below 5 mm in 94.9% of the recorded fields. Mean Displacement was less in cranio-caudal direction. Mean intra-fraction displacement was below 3 mm in all directions. vDIBH plans provided better cardiac dosimetry.
vDIBH technique using ExacTrac (BrainLAB AG, Germany) monitoring system was applied with good reproducibility.
自愿深吸气屏气技术(vDIBH)被认为是实现全乳照射中心脏最大程度保护的关键。已经实施了几种技术以实现可重复、快速和友好的治疗。本研究的目的是使用 ExacTrac(德国 BrainLAB AG)监测系统实施 vDIBH。
年龄小于 50 岁或有心脏病的左侧乳腺癌女性接受全乳放疗,使用 ExacTrac(德国 BrainLAB AG)监测系统进行 vDIBH。模拟时,患者仰卧在乳房板上,双臂举过头顶。在左乳房边缘的皮肤上放置五个光学标记物,并以墨水标记其位置。每位患者都接受了一次培训课程,以找到个人的深吸气水平。最后,进行了 vDIBH CT 扫描。所有患者还在自由呼吸(FB)中进行了研究,以比较 PTV、心脏和左前降支冠状动脉(LAD)的剂量分布。通过 ExacTrac(德国 BrainLAB AG)系统进行了治疗前验证,并通过电子门户成像(EPI)进行了验证。此外,在治疗期间(在束流传输过程中捕获)拍摄了每日实时 EPI,以检查可重复性。
对 34 例患者进行了评估,其中 30 例符合 vDIBH 条件。在记录的 94.9%的射野中,大多数患者在治疗过程中的设置误差较小,均小于 5 毫米。头脚方向的平均位移较小。在所有方向上,平均分次内位移均小于 3 毫米。vDIBH 计划提供了更好的心脏剂量学。
使用 ExacTrac(德国 BrainLAB AG)监测系统的 vDIBH 技术具有良好的可重复性。