Department of Neurosurgery at Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Department of Pathology at Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
J Neuropathol Exp Neurol. 2018 Jul 1;77(7):549-554. doi: 10.1093/jnen/nly029.
Tumor-to-tumor metastasis is an uncommon phenomenon, and a metastasis from an extracranial donor tumor to an intracranial recipient tumor is extremely rare. In particular, there are only 14 cases reported in the literature that describe a tumor-to-tumor metastasis involving a glioma. We present a rare case of an 83-year-old man with an 11-year history of lentigo maligna melanoma who presented with impaired balance and cognitive slowing and was found to have rapid progression of a previously known indolent right frontal brain mass. Pathologic examination of the tumor after resection revealed the presence of both malignant melanoma and an oligodendroglioma WHO grade II. To the best of our knowledge, this is the first reported case of malignant melanoma metastasizing to an oligodendroglioma that has been confirmed by immunohistochemistry and genetic analysis.
肿瘤对肿瘤转移是一种罕见的现象，而颅外供体肿瘤向颅内受体肿瘤转移则极为罕见。特别是，文献中仅报道了 14 例描述涉及神经胶质瘤的肿瘤对肿瘤转移的病例。我们报告了一例罕见的 83 岁男性病例，该患者患有 11 年的恶性雀斑样痣黑色素瘤病史，表现为平衡障碍和认知迟缓，并发现先前已知的惰性右额叶脑肿块迅速进展。切除后的肿瘤病理检查显示同时存在恶性黑色素瘤和少突胶质细胞瘤 WHO 分级 II。据我们所知，这是首例通过免疫组织化学和基因分析证实的恶性黑色素瘤转移至少突胶质细胞瘤的病例。
