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Association of History of Gestational Diabetes With Long-term Cardiovascular Disease Risk in a Large Prospective Cohort of US Women.美国大型前瞻性女性队列研究中妊娠糖尿病史与长期心血管疾病风险的关系。
JAMA Intern Med. 2017 Dec 1;177(12):1735-1742. doi: 10.1001/jamainternmed.2017.2790.
2
Association of Positive Airway Pressure With Cardiovascular Events and Death in Adults With Sleep Apnea: A Systematic Review and Meta-analysis.成人睡眠呼吸暂停患者气道正压通气与心血管事件及死亡的关联:一项系统评价和荟萃分析。
JAMA. 2017 Jul 11;318(2):156-166. doi: 10.1001/jama.2017.7967.
3
Role of Carotid Body in Intermittent Hypoxia-Related Hypertension.颈动脉体在间歇性低氧相关高血压中的作用。
Curr Hypertens Rep. 2017 May;19(5):38. doi: 10.1007/s11906-017-0735-0.
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Inflammation-induced fetal growth restriction in rats is associated with increased placental HIF-1α accumulation.炎症引起的大鼠胎儿生长受限与胎盘 HIF-1α 积累增加有关。
PLoS One. 2017 Apr 19;12(4):e0175805. doi: 10.1371/journal.pone.0175805. eCollection 2017.
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Continuous Ropivacaine Subfascial Wound Infusion Compared With Intrathecal Morphine for Postcesarean Analgesia: A Prospective, Randomized Controlled, Double-Blind Study.连续罗哌卡因筋膜下伤口输注与鞘内注射吗啡用于剖宫产术后镇痛的比较:一项前瞻性、随机对照、双盲研究。
Anesth Analg. 2017 Sep;125(3):907-912. doi: 10.1213/ANE.0000000000001892.
6
Oxidative and carbonyl stress in pregnant women with obstructive sleep apnea.患有阻塞性睡眠呼吸暂停的孕妇的氧化应激和羰基应激
Sleep Breath. 2018 Mar;22(1):233-240. doi: 10.1007/s11325-017-1475-8. Epub 2017 Feb 24.
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Effect of early-onset preeclampsia on cardiovascular risk in the fifth decade of life.早发型子痫前期对五十岁年龄段心血管风险的影响。
Am J Obstet Gynecol. 2017 May;216(5):523.e1-523.e7. doi: 10.1016/j.ajog.2017.02.015. Epub 2017 Feb 14.
8
Clinical Practice Guideline for Diagnostic Testing for Adult Obstructive Sleep Apnea: An American Academy of Sleep Medicine Clinical Practice Guideline.成人阻塞性睡眠呼吸暂停诊断检测临床实践指南:美国睡眠医学学会临床实践指南
J Clin Sleep Med. 2017 Mar 15;13(3):479-504. doi: 10.5664/jcsm.6506.
9
Repeated measures of inflammation and oxidative stress biomarkers in preeclamptic and normotensive pregnancies.子痫前期和血压正常妊娠中炎症和氧化应激生物标志物的重复测量。
Am J Obstet Gynecol. 2017 May;216(5):527.e1-527.e9. doi: 10.1016/j.ajog.2016.12.174. Epub 2016 Dec 30.
10
Association of obstructive sleep apnea with adverse pregnancy-related outcomes in military hospitals.军事医院中阻塞性睡眠呼吸暂停与不良妊娠相关结局的关联
Eur J Obstet Gynecol Reprod Biol. 2017 Mar;210:166-172. doi: 10.1016/j.ejogrb.2016.12.013. Epub 2016 Dec 14.

妊娠期阻塞性睡眠呼吸暂停的管理。

Management of Obstructive Sleep Apnea in Pregnancy.

机构信息

Department of Anesthesiology, Obstetric Anesthesiology, Division of Women's Anesthesia, Duke University Medical Center, Mail Sort #9, DUMC Box 3094, Durham, NC 27710, USA.

Division of Maternal Fetal Medicine, Department of OB/GYN, Medical College of Georgia, Augusta University, 1120 15th Street, BA-7410, Augusta, GA 30912, USA.

出版信息

Obstet Gynecol Clin North Am. 2018 Jun;45(2):233-247. doi: 10.1016/j.ogc.2018.01.001.

DOI:10.1016/j.ogc.2018.01.001
PMID:29747728
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5995135/
Abstract

The spectrum of sleep-disordered breathing (SDB) ranges from mild snoring to obstructive sleep apnea, the most severe form of SDB. Current recommendations are to treat these women with continuous positive airway pressure despite limited data. SDB in early and mid-pregnancy is associated with preeclampsia and gestational diabetes. Pregnant women with a diagnosis of obstructive sleep apnea at delivery were at significantly increased risk of having cardiomyopathy, congestive heart failure, pulmonary embolism, and in-hospital death. These effects were exacerbated in the presence of obesity. Postpartum, these women are at risk for respiratory suppression and should be monitored.

摘要

睡眠呼吸紊乱(SDB)的范围从轻度打鼾到阻塞性睡眠呼吸暂停,这是 SDB 最严重的形式。尽管数据有限,但目前的建议是对这些女性进行持续气道正压通气治疗。妊娠早期和中期的 SDB 与先兆子痫和妊娠期糖尿病有关。分娩时诊断为阻塞性睡眠呼吸暂停的孕妇发生心肌病、充血性心力衰竭、肺栓塞和院内死亡的风险显著增加。肥胖使这些影响更加严重。产后,这些女性有呼吸抑制的风险,应进行监测。