Chemistry Division , Los Alamos National Laboratory , P.O. Box 1663, Los Alamos , New Mexico 87545 , United States.
Nuclear Security and Isotope Technology Division , Oak Ridge National Laboratory , Oak Ridge , Tennessee 37831 , United States.
Anal Chem. 2018 Jun 5;90(11):7012-7017. doi: 10.1021/acs.analchem.8b01380. Epub 2018 May 24.
Protactinium-230 ( t = 17.4 d) is the parent isotope of U ( t = 20.8 d), a radionuclide of interest for targeted alpha therapy (TAT). Column chromatographic methods have been developed to separate no-carrier-added Pa from proton irradiated thorium targets and accompanying fission products. Results reported within demonstrate the use of novel sulfur bearing chromatographic extraction resins for the selective separation of protactinium. The recovery yield of Pa was 93 ± 4% employing a RP═S type commercially available resin and 88 ± 4% employing a DGTA (diglycothioamide) containing custom synthesized extraction chromatographic resin. The radiochemical purity of the recovered Pa was measured via high purity germanium γ-ray spectroscopy to be >99.5% with the remaining radioactive contaminant being Nb due to its similar chemistry to protactinium. Measured equilibrium distribution coefficients for protactinium, thorium, uranium, niobium, radium, and actinium on both the RP═S type and the DGTA resin in hydrochloric acid media are reported, to the best of our knowledge, for the first time.
镤-230（t = 17.4 d）是铀（t = 20.8 d）的母同位素，是靶向α治疗（TAT）中感兴趣的放射性核素。已经开发出柱色谱方法来分离质子辐照钍靶和伴随的裂变产物中的无载体添加镤。本文报告的结果表明，新型含硫色谱萃取树脂可用于选择性分离镤。采用 RP═S 型市售树脂，镤的回收率为 93 ± 4%，采用含有定制合成萃取色谱树脂的 DGTA（双甘氨硫代酰胺），镤的回收率为 88 ± 4%。采用高纯锗γ射线能谱法测定回收镤的放射化学纯度>99.5%，其余放射性污染物为铌，因为其化学性质与镤相似。据我们所知，这是首次在盐酸介质中报告 RP═S 型和 DGTA 树脂上镤、钍、铀、铌、镭和锕的平衡分配系数。
Zotero 插件