Department of Obstetrics and Gynecology, Stavanger University Hospital, Stavanger, Norway; Department of Clinical Science, University of Bergen, Bergen, Norway.
Department of Obstetrics and Gynecology, Stavanger University Hospital, Stavanger, Norway.
J Reprod Immunol. 2018 Jun;127:43-47. doi: 10.1016/j.jri.2018.04.004. Epub 2018 Apr 20.
Immunological mechanisms underlying the development of preeclampsia are well known, but no association to allergy has yet been demonstrated. The aim of this study was to assess the correlation between maternal pre-gestational allergy, and early-onset and late-onset preeclampsia, respectively. It was a retrospective cohort study including all women giving birth in the Norwegian cities of Stavanger (1996-2014) and Bergen (2009-2014). Pre-gestational asthma, allergy, other known risk factors for preeclampsia, maternal age and parity were obtained from the electronic medical record system. The main outcome variables were early-onset and late-onset preeclampsia (before and after 34 completed weeks of gestation, respectively). We used multinomial logistic regression to estimate odds ratios (OR) with 95% confidence intervals (95% CI) for early and late-onset preeclampsia in women with pre-gestational allergy when compared to women without allergy, adjusting for covariates. Predicted probabilities for the outcomes were also calculated. Of the 110 064 included pregnancies, 2 799 developed late-onset preeclampsia (2.5%) and 348 developed early-onset preeclampsia (0.3%). Pre-gestational allergy increased the risk of early-onset preeclampsia (OR 1.7, 95% CI 1.3-2.4), and reduced the risk of late-onset preeclampsia (OR 0.8, 95% CI 0.7-0.9). These findings add valuable information on preeclampsia as an immunological complication of pregnancy and corroborate the understanding of early- and late-onset preeclampsia as two different entities.
子痫前期发展的免疫机制众所周知，但尚未证明与过敏有关。本研究旨在评估母亲孕前过敏与早发型和晚发型子痫前期的相关性。这是一项回顾性队列研究，纳入了 1996 年至 2014 年在挪威斯塔万格市和 2009 年至 2014 年在卑尔根市分娩的所有妇女。孕前哮喘、过敏、子痫前期的其他已知危险因素、母亲年龄和产次均从电子病历系统中获得。主要结局变量为早发型和晚发型子痫前期（分别为妊娠 34 周前和 34 周后）。我们使用多变量逻辑回归估计了孕前有过敏的妇女与无过敏的妇女相比，早发型和晚发型子痫前期的优势比（OR）及其 95%置信区间（95%CI），并对协变量进行了调整。还计算了结局的预测概率。在纳入的 110064 例妊娠中，2799 例发生晚发型子痫前期（2.5%），348 例发生早发型子痫前期（0.3%）。孕前过敏增加了早发型子痫前期的风险（OR 1.7，95%CI 1.3-2.4），降低了晚发型子痫前期的风险（OR 0.8，95%CI 0.7-0.9）。这些发现为子痫前期作为妊娠的免疫并发症提供了有价值的信息，并证实了早发型和晚发型子痫前期作为两种不同实体的理解。
