阻塞性睡眠呼吸暂停的药物治疗
Drug Therapy in Obstructive Sleep Apnea.
作者信息
Hedner Jan, Zou Ding
机构信息
Department of Internal Medicine and Clinical Nutrition, Center for Sleep and Vigilance Disorders, Sahlgrenska Academy, University of Gothenburg, Medicinaregatan 8B, Box 421, Gothenburg SE-40530, Sweden.
Department of Internal Medicine and Clinical Nutrition, Center for Sleep and Vigilance Disorders, Sahlgrenska Academy, University of Gothenburg, Medicinaregatan 8B, Box 421, Gothenburg SE-40530, Sweden.
出版信息
Sleep Med Clin. 2018 Jun;13(2):203-217. doi: 10.1016/j.jsmc.2018.03.004.
There are several reasons to develop a pharmacologic remedy in obstructive sleep apnea (OSA); but so far, there is no generally effective drug available. Previous attempts to find a drug in OSA therapy were serendipity driven in small pilot trials. There is growing literature on phenotyping pathophysiologic mechanisms of OSA that may be exploited in strategic drug development programs. The current review addresses potential pitfalls encountered in previous studies and highlights several drug candidates under development in the field.
开发阻塞性睡眠呼吸暂停（OSA）药物治疗方法有几个原因；但到目前为止，还没有普遍有效的药物。以前在OSA治疗中寻找药物的尝试是在小型试点试验中偶然进行的。关于OSA病理生理机制表型分析的文献越来越多，这些机制可能会在战略药物开发项目中得到利用。本综述阐述了先前研究中遇到的潜在问题，并强调了该领域正在研发的几种候选药物。
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