Department of Neurology Charité - University Medicine Berlin, CBF Berlin Germany.
Faculty of Psychology and Neuroscience Maastricht University Maastricht Netherlands.
Brain Behav. 2018 Apr 16;8(5):e00976. doi: 10.1002/brb3.976. eCollection 2018 May.
The complex symptomatology of Parkinson' disease (PD) usually goes along with reduced physical activity. Previous studies have indicated positive effects of activating therapies on patients' well-being. This study, therefore, examined how activity in daily life is related to patients' subjective condition.
Twenty-one PD patients rated their condition every two hours during two routine days and documented the duration and type of their activities (based on the PRISCUS-Physical Activity Questionnaire) during the respective time intervals. They were furthermore assessed regarding motor and nonmotor symptoms, personality factors, and coping strategies.
Patients spent on average 8.59 ± 2.93 hr per day at physical rest and 5.47 ± 2.93 hr physically active. We found highly significant associations between positive condition ratings (such as happiness, motivation, and concentration) and the duration of subsequent physical activities ( = .689) as well as between the duration of these activities and a subsequent improvement in the subjective condition ( = .545). This was strongest in patients using active coping strategies and showing agreeable and conscientious personality traits ( = .380). Nonmotor symptom severity was weakly inversely related to the daily amount of activities ( = .273), whereas no significant association with motor symptom severity was found.
The results suggest a feedback process between a positive subjective condition and physical activities in PD patients. This appears to depend on the use of active coping strategies and nonmotor symptoms rather than on motor symptom severity. The results should encourage physicians to address the importance of everyday physical activities and to provide patients with behavioral advice.
帕金森病（PD）的复杂症状通常伴随着身体活动减少。先前的研究表明激活疗法对患者的幸福感有积极影响。因此，本研究探讨了日常生活中的活动如何与患者的主观状况相关。
21 名 PD 患者在两天的常规时间内每两小时评估一次自己的病情，并在各自的时间间隔内记录活动的持续时间和类型（基于 PRISCUS-Physical Activity Questionnaire）。此外，还评估了他们的运动和非运动症状、人格因素和应对策略。
患者平均每天在身体休息时花费 8.59 ± 2.93 小时，在身体活动时花费 5.47 ± 2.93 小时。我们发现积极的病情评分（如幸福感、动力和注意力）与随后的身体活动持续时间之间存在高度显著的关联（ =.689），以及这些活动的持续时间与随后主观状况的改善之间存在显著的关联（ =.545）。对于使用积极应对策略和表现出亲和和尽责人格特质的患者来说，这种关联最强（ =.380）。非运动症状严重程度与日常活动量呈弱负相关（ =.273），而与运动症状严重程度无显著相关性。
结果表明，PD 患者的积极主观状况和身体活动之间存在反馈过程。这似乎取决于积极应对策略和非运动症状的使用，而不是运动症状的严重程度。这些结果应鼓励医生重视日常身体活动的重要性，并为患者提供行为建议。
