埃塞俄比亚儿童中高效抗逆转录病毒疗法的依从性：系统评价和荟萃分析。
Adherence to Highly Active Antiretroviral Therapy Among Children in Ethiopia: A Systematic Review and Meta-analysis.
机构信息
Department of Pediatrics and Child Health Nursing, School of Nursing, College of Medicine and Health Sciences, University of Gondar, P.O. BOX: 196, Gondar, Ethiopia.
Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
出版信息
AIDS Behav. 2018 Aug;22(8):2513-2523. doi: 10.1007/s10461-018-2152-z.
Adherence to highly active antiretroviral therapy (HAART) is the mainstay of the strategy in reducing morbidity and mortality of HIV-infected children. Different primary studies were conducted in Ethiopia. Thus, we aimed to conduct a meta-analysis of the national prevalence of optimal adherence to HAART in children. In addition, associated factors of HAART adherence were reviewed. A weighted inverse variance random-effects model was applied. The 88.7 and 93.7% of children were adhering to HAART at 07 and 03 days prior to an interview respectively. The subgroup analysis showed that HAART adherence was 93.4% in Amhara, 90.1% in Addis Ababa and 87.3% in Tigray at 07 days prior to an interview. Our study suggests that, within short window reported time, adherence to HAART in Ethiopian children may be in a good progress. Emphasis on specific adherence interventions need further based on individual predictors to improve overall HAART adherence of children.
抗逆转录病毒疗法（HAART）的依从性是降低 HIV 感染儿童发病率和死亡率的主要策略。在埃塞俄比亚进行了不同的初步研究。因此，我们旨在对全国儿童接受 HAART 最佳依从性的患病率进行荟萃分析。此外，还审查了与 HAART 依从性相关的因素。采用加权倒数方差随机效应模型。在接受访谈前 07 天和 03 天，分别有 88.7%和 93.7%的儿童坚持接受 HAART。亚组分析表明，在接受访谈前 07 天，HAART 的依从率在阿姆哈拉为 93.4%，在亚的斯亚贝巴为 90.1%，在提格雷为 87.3%。我们的研究表明，在报告的短时间窗口内，埃塞俄比亚儿童对 HAART 的依从性可能在取得良好的进展。需要根据个体预测因素进一步强调特定的依从性干预措施，以提高儿童整体 HAART 的依从性。
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