激动剂和拮抗剂对多巴胺D1和D2受体的选择性
Dopamine D1 and D2 receptor selectivities of agonists and antagonists.
作者信息
Seeman P, Ulpian C
机构信息
Department of Pharmacology, University of Toronto, Canada.
出版信息
Adv Exp Med Biol. 1988;235:55-63. doi: 10.1007/978-1-4899-2723-1_5.
The selectivities of various dopamine agonists and antagonists for dopamine D1 and D2 receptors were obtained by comparing their relative dissociation constants for inhibiting the binding of [3H]SCH 23390 at D1 receptors (calf caudate nucleus) and at D2 receptors (pig anterior pituitary tissue). The most selective agonists were SK&F 38393 (for D1) and (+)-PHNO (for D2), while the most selective antagonists were SCH 23390 (for D1) and raclopride or eticlopride (for D2).
通过比较各种多巴胺激动剂和拮抗剂抑制[³H]SCH 23390在D1受体（小牛尾状核）和D2受体（猪垂体前叶组织）上结合的相对解离常数，得出它们对多巴胺D1和D2受体的选择性。选择性最高的激动剂是SK&F 38393（针对D1）和（+）-PHNO（针对D2），而选择性最高的拮抗剂是SCH 23390（针对D1）和雷氯必利或依替必利（针对D2）。
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