König W, Pfeil P, Hofmann U, Bujanowski-Weber J, Knöller I
Med. Mikrobiologie und Immunologie, Ruhr-Universität Bochum, Federal Republic of Germany.
Allergol Immunopathol (Madr). 1988 Jul-Aug;16(4):203-8.
The low affinity receptor for IgE (Fc epsilon RII), which is identical to CD 23 has been recently implicated in a variety of functions. It appears as an early stage specific marker in the ontogeny of the IgM-bearing B cell. In humans the CD 23 is also exposed on T-cells in patients with elevated IgE, while in rodents Fc epsilon RII seems to be mainly present on T-lymphocytes. Fc epsilon RII can also be detected on macrophages, eosinophils and platelets. Activation of these cells induces an amplification of the inflammatory response. It is currently suggested that IgE-binding molecules, which are related to CD 23, modulate IgE synthesis according to their degree of glycosylation. Evidence has been provided recently that interleukin 4 induces the expression of Fc epsilon RII (CD23). The action of interleukins, IgE binding factors and cytokines on the complex events of IgE-induction and synthesis are currently studied.
