Department of Gastroenterology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Shanghai Institute of Digestive Disease, Shanghai, China.
Am J Epidemiol. 2018 Sep 1;187(9):1829-1839. doi: 10.1093/aje/kwy083.
Definitions and descriptions of acute-on-chronic liver failure (ACLF) vary between Western and Eastern types, and alcoholism and hepatitis B virus (HBV) are, respectively, the main etiologies. To determine whether there are unified diagnostic criteria and common treatment programs for different etiologies of ACLF, a multicenter prospective cohort with the same inclusion criteria and disease indicators as those used in the European Consortium Acute-on-Chronic Liver Failure in Cirrhosis Study is urgently needed in Asia, where the prevalence of HBV is high. A multicenter prospective cohort of 2,600 patients was designed, drawing from 14 nationwide liver centers from tertiary university hospitals in China, and 2,600 hospitalized patients with chronic liver disease (both cirrhotic and noncirrhotic) of various etiologies with acute decompensation or acute hepatic injury were continuously recruited from January 2015 to December 2016. Data were collected during hospitalization, and follow-ups were performed once a month, with plans to follow all patients until 36 months after hospital discharge. Of these patients, 1,859 (71.5%) had HBV-related disease, 1,833 had cirrhotic disease, and 767 had noncirrhotic disease. The numbers and proportions of enrolled patients from each participating center and the baseline characteristics of the patients with or without cirrhosis are presented.
定义和描述的急性肝衰竭（ACLF）之间的西方和东方类型的不同，和酒精中毒和乙型肝炎病毒（HBV）分别是主要病因。为了确定是否有统一的诊断标准和共同的治疗方案为不同病因的 ACLF，多中心前瞻性队列与相同的纳入标准和疾病指标用于欧洲联盟急性肝衰竭在肝硬化研究中是迫切需要在亚洲，乙型肝炎病毒（HBV）的流行率高。多中心前瞻性队列的 2600 例患者，从中国的 14 个全国性的肝脏中心从大学医院的三级设计，和 2600 例住院的慢性肝脏疾病（肝硬化和非肝硬化）与急性失代偿或急性肝损伤不断招募从 2015 年 1 月到 2016 年 12 月。数据收集在住院期间，并进行每月一次的随访，计划随访所有患者直到出院后 36 个月。这些患者中，有 1859 例（71.5%）与 HBV 相关疾病，1833 例有肝硬化，767 例非肝硬化。从每个参与中心的患者人数和比例和基线特征的患者有或没有肝硬化。
