Department of Hematology, Diskapi Training and Research Hospital, Ankara, Turkey, KBU Karabuk Research and Educational Hospital, Department of Internal Medicine, Karabuk, Turkey.
Eur Rev Med Pharmacol Sci. 2018 Apr;22(8):2246-2252. doi: 10.26355/eurrev_201804_14811.
The aim of this study was to identify the relationship between complete blood count parameters, mean platelet volume (MPV), and platelet to lymphocyte ratio (PLR) with mortality and hospitalization duration in critically ill patients.
A retrospective analysis was made of patients admitted to our tertiary adult i̇ntensive Care Unit (ICU) between January 2015 and January 2016. Hemoglobin (Hb), white blood cell (WBC), lymphocyte and platelet counts were obtained from the complete blood count performed at the time of admission. MPV and PLR levels were calculated from these data. Other data were retrieved from the patient follow-up records.
The investigation included a total of 306 patients. The total mortality rate was 40.2%. The initial median PLR level was 206.7 (8.1-1675.0) for non-survivor patients and 194.5 (12.8-1236.6) for survivor patients. The PLR level was higher in the non-survivor group, but there was no statistically significant difference between the groups (p>0.05). The median MPV level was 7.66 (5.17-15.25) for the survivors and 8.09 (4.36-16.19) for the non-survivors, and there was no statistically significant difference between the groups (p=0.237). The median length of stay (LOS) of all patients was 7 (2-61) days. Only the Acute Physiology and Chronic Health Evaluation (APACHE) II score was found to have a positive correlation with LOS (p<0.05).
PLR has no effect on mortality rates regardless of whether the patient has thrombocytopenia or not at the time of admission. MPV levels have no significant relationship with mortality. Neither MPV nor PLR have an effect on LOS. The use of these as a prognostic factor for mortality in critically ill patients is still unclear.
本研究旨在确定全血细胞参数、血小板平均体积（MPV）和血小板与淋巴细胞比值（PLR）与危重症患者死亡率和住院时间的关系。
对 2015 年 1 月至 2016 年 1 月间入住我院成人重症监护病房（ICU）的患者进行回顾性分析。入院时进行全血细胞计数，获得血红蛋白（Hb）、白细胞（WBC）、淋巴细胞和血小板计数。根据这些数据计算 MPV 和 PLR 水平。其他数据从患者随访记录中检索。
共纳入 306 例患者，总死亡率为 40.2%。非幸存者患者初始中位数 PLR 水平为 206.7（8.1-1675.0），幸存者患者为 194.5（12.8-1236.6）。非幸存者组 PLR 水平较高，但组间无统计学差异（p＞0.05）。幸存者组的中位 MPV 水平为 7.66（5.17-15.25），非幸存者组为 8.09（4.36-16.19），组间无统计学差异（p=0.237）。所有患者的中位住院时间（LOS）为 7（2-61）天。仅急性生理学和慢性健康评估（APACHE）Ⅱ评分与 LOS 呈正相关（p＜0.05）。
PLR 对死亡率无影响，无论患者入院时是否伴有血小板减少症。MPV 水平与死亡率无显著相关性。MPV 和 PLR 对 LOS 均无影响。这些指标作为危重症患者死亡率的预后因素仍不明确。
